Microbiological etiologies of pneumonia complicating stroke: A systematic review

Research output: Contribution to journalArticle

  • Authors:
  • Pneumonia In Stroke ConsEnsuS (PISCES) Group
  • Amit Kishore
  • Andy Vail
  • Adam R. Jeans
  • Angel Chamorro
  • Mario Di Napoli
  • Lalit Kalra
  • Peter Langhorne
  • Christine Roffe
  • Willeke Westendorp
  • Paul J. Nederkoorn
  • Javier Garau
  • Diederik van de Beek
  • Joan Montaner
  • Mark Woodhead
  • Andreas Meisel
  • Craig Smith

Abstract

Background and Purpose—
Identifying the causal pathogens of pneumonia complicating stroke is challenging, and antibiotics used are often broad spectrum, without recourse to the microbiological cause. We aimed to review existing literature to identify organisms responsible for pneumonia complicating stroke, before developing a consensus-based approach to antibiotic treatment.

Methods—
A systematic literature review of multiple electronic databases using predefined search criteria was undertaken, in accordance with Cochrane and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidance. Published studies of hospitalized adults with ischemic stroke, intracerebral hemorrhage, or both, which identified microbiological etiologies for pneumonia complicating stroke up to January 1, 2017, were considered. Analysis included summary statistics and random-effects meta-analysis where appropriate.

Results—
Fifteen studies (40% ischemic stroke, 60% ischemic stroke and intracerebral hemorrhage) involving 7968 patients were included. Reported occurrence of pneumonia varied considerably between studies (2%–63%) with a pooled frequency of 23% (95% confidence interval, 14%–34%; I2=99%). Where reported (60%), the majority of pneumonia occurred within 1 week of stroke (78%). Reported frequency of positive culture data (15%–88%) varied widely. When isolated, aerobic Gram-negative bacilli (38%) and Gram-positive cocci (16%) were most frequently cultured; commonly isolated organisms included Enterobacteriaceae (21.8%: Klebsiella pneumoniae, 12.8% and Escherichia coli, 9%), Staphylococcus aureus (10.1%), Pseudomonas aeruginosa (6%), Acinetobacter baumanii (4.6%), and Streptococcus pneumoniae (3.5%). Sputum was most commonly used to identify pathogens, in isolation (40%) or in conjunction with tracheal aspirate (15%) or blood culture (20%).

Conclusions—
Although the analysis was limited by small and heterogeneous study populations, limiting determination of microbiological causality, this review suggests aerobic Gram-negative bacilli and Gram-positive cocci are frequently associated with pneumonia complicating stroke. This supports the need for appropriately designed studies to determine microbial cause and a consensus-based approach in antibiotic usage and further targeted antibiotic treatment trials for enhanced antibiotic stewardship.

Bibliographical metadata

Original languageEnglish
JournalStroke
Volume49
Issue number7
Early online date30 Jul 2018
DOIs
Publication statusPublished - Jul 2018

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