Metal-free intermolecular aminoarylation of alkynes

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A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4183–4186
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number15
Early online date13 Mar 2017
Publication statusPublished - 3 Apr 2017

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