Metal-free intermolecular aminoarylation of alkynes

Research output: Contribution to journalArticle

Abstract

A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4183–4186
Number of pages4
JournalAngewandte Chemie - International Edition
Volume56
Issue number15
Early online date13 Mar 2017
DOIs
StatePublished - 3 Apr 2017