Melatonin in the skin: synthesis, metabolism and functions.Citation formats

  • Authors:
  • Andrzej Slominski
  • Desmond J. Tobin
  • Michal A. Zmijewski
  • Jacobo Wortsman
  • Ralf Paus

Standard

Melatonin in the skin: synthesis, metabolism and functions. / Slominski, Andrzej; Tobin, Desmond J.; Zmijewski, Michal A.; Wortsman, Jacobo; Paus, Ralf.

In: Trends in Endocrinology and Metabolism, Vol. 19, No. 1, 01.2008, p. 17-24.

Research output: Contribution to journalArticlepeer-review

Harvard

Slominski, A, Tobin, DJ, Zmijewski, MA, Wortsman, J & Paus, R 2008, 'Melatonin in the skin: synthesis, metabolism and functions.', Trends in Endocrinology and Metabolism, vol. 19, no. 1, pp. 17-24. https://doi.org/10.1016/j.tem.2007.10.007

APA

Slominski, A., Tobin, D. J., Zmijewski, M. A., Wortsman, J., & Paus, R. (2008). Melatonin in the skin: synthesis, metabolism and functions. Trends in Endocrinology and Metabolism, 19(1), 17-24. https://doi.org/10.1016/j.tem.2007.10.007

Vancouver

Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends in Endocrinology and Metabolism. 2008 Jan;19(1):17-24. https://doi.org/10.1016/j.tem.2007.10.007

Author

Slominski, Andrzej ; Tobin, Desmond J. ; Zmijewski, Michal A. ; Wortsman, Jacobo ; Paus, Ralf. / Melatonin in the skin: synthesis, metabolism and functions. In: Trends in Endocrinology and Metabolism. 2008 ; Vol. 19, No. 1. pp. 17-24.

Bibtex

@article{bce9e6b9e25544bda69d01ed5a34154f,
title = "Melatonin in the skin: synthesis, metabolism and functions.",
abstract = "Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin. Melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cells. Melatonin has both receptor-dependent and receptor-independent effects that protect against oxidative stress and can attenuate ultraviolet radiation-induced damage. The widespread expression and pleiotropic activity of the cutaneous melatoninergic system provides for a high level of cell-specific selectivity. Moreover, intra-, auto- and para-crine mechanisms equip this system with exquisite functional selectivity. The properties of endogenous melatonin suggest that this molecule is an important effector of stress responses in the skin. In this way, melatonin actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity.",
author = "Andrzej Slominski and Tobin, {Desmond J.} and Zmijewski, {Michal A.} and Jacobo Wortsman and Ralf Paus",
year = "2008",
month = jan,
doi = "10.1016/j.tem.2007.10.007",
language = "English",
volume = "19",
pages = "17--24",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - Melatonin in the skin: synthesis, metabolism and functions.

AU - Slominski, Andrzej

AU - Tobin, Desmond J.

AU - Zmijewski, Michal A.

AU - Wortsman, Jacobo

AU - Paus, Ralf

PY - 2008/1

Y1 - 2008/1

N2 - Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin. Melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cells. Melatonin has both receptor-dependent and receptor-independent effects that protect against oxidative stress and can attenuate ultraviolet radiation-induced damage. The widespread expression and pleiotropic activity of the cutaneous melatoninergic system provides for a high level of cell-specific selectivity. Moreover, intra-, auto- and para-crine mechanisms equip this system with exquisite functional selectivity. The properties of endogenous melatonin suggest that this molecule is an important effector of stress responses in the skin. In this way, melatonin actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity.

AB - Melatonin, a ubiquitous methoxyindole, is produced by and metabolized in the skin. Melatonin affects skin functions and structures through actions mediated by cell-surface and putative-nuclear receptors expressed in skin cells. Melatonin has both receptor-dependent and receptor-independent effects that protect against oxidative stress and can attenuate ultraviolet radiation-induced damage. The widespread expression and pleiotropic activity of the cutaneous melatoninergic system provides for a high level of cell-specific selectivity. Moreover, intra-, auto- and para-crine mechanisms equip this system with exquisite functional selectivity. The properties of endogenous melatonin suggest that this molecule is an important effector of stress responses in the skin. In this way, melatonin actions may counteract or buffer both environmental and endogenous stressors to maintain skin integrity.

U2 - 10.1016/j.tem.2007.10.007

DO - 10.1016/j.tem.2007.10.007

M3 - Article

C2 - 18155917

VL - 19

SP - 17

EP - 24

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 1

ER -