Mechanisms of adiponectin-associated perivascular function in vascular disease

Research output: Contribution to journalArticle

  • External authors:
  • Sarah Withers
  • Charlotte Bussey
  • Heather Melrose
  • Amy Watkins


The concept that fat cells could influence the circulation and indeed cardiac function has been in existence for ≥20 years and has gained a wide interest and no less excitement as evidence has accrued to suggest that such effects may be profound enough to explain disease states, such as hypertension and metabolic changes associated with obesity and type II diabetes mellitus. This ATVB in Focus intends to examine our current knowledge in this field, and suggests mechanisms that may be responsible for normal perivascular function and how they become disordered in obesity. There is the tantalizing prospect of developing new therapeutic approaches to keep obese individuals healthy and redesignating type II diabetes mellitus as a vascular disease.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1637-1642
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number8
Publication statusPublished - Aug 2014