Mechanism of cellular interaction, binding and internalization of functionalized carbon nanotubes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The interaction between cells and carbon nanotubes (CNT) is a critical issue that will determine any future biological application of such structures. In this communication we will show that various types of functionalized-carbon nanotubes (f-CNT) exhibit a capacity to be uptaken by a wide range of cells (prokaryotic and eukaryotic) and can intracellularly traffick through different cellular barriers[1, 2] The mechanism by which f-CNT are able to cross cell membranes and deliver their cargo will also be discussed. Energy-independent mechanisms are explained based on the cylindrical shape and high aspect ratio of f-CNT that can allow their penetration through the plasma membrane, similar to a 'nanosyringe'[3].

Bibliographical metadata

Original languageEnglish
Title of host publicationNanotechnology 2008: life science, medicine, and bio materials.
Place of PublicationBoston
PublisherCRC Press
Pages232-325
Volume2
ISBN (Print)9781420085075
Publication statusPublished - 2008

Publication series

NameNsti Nanotech 2008, Vol 2, Technical Proceedings