Maternal obesity and its effect on placental cell turnover

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Abstract

Background: Maternal obesity is a frequent obstetric risk factor, linked with short-and long-term consequences for mother and child, including foetal overgrowth, growth restriction and stillbirth. The mechanisms underlying these pathologies remain unknown but likely involve the placenta. Aims: To study placental cell turnover in relation to maternal body mass index (BMI). Methods: Term placental villous tissue was randomly sampled from 24 pregnancies, with a range of maternal BMI of 19.5-49.6. Immunohistochemistry was performed for human chorionic gonadotropin, Ki67 and M30 and image analysis used to calculate syncytiotrophoblast area and proliferative and apoptotic indices. Results were compared categorically between women of BMI 18.5-24.9 (normal), BMI 30.0-39.9 (obese classes 1and 2) and BMI 40+ (obese class 3) and continuously against BMI; p

Bibliographical metadata

Original languageEnglish
Pages (from-to)783-788
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume26
Issue number8
DOIs
Publication statusPublished - May 2013