Maternal growth factor regulation of human placental development and fetal growthCitation formats

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Maternal growth factor regulation of human placental development and fetal growth. / Forbes, Karen; Westwood, Melissa.

In: Journal of Endocrinology, Vol. 207, No. 1, 10.2010, p. 1-16.

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@article{ca686c22ab594c9a9784ff0d7f9684f4,
title = "Maternal growth factor regulation of human placental development and fetal growth",
abstract = "Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development and function. Although these factors act via distinct receptors to exert their effects, the downstream molecules activated upon ligand/receptor interaction are common to many growth factors. The expression of numerous signaling molecules is altered in the placentas from pregnancies affected by the fetal growth complications, fetal growth restriction, and macrosomia. Thus, targeting these molecules may lead to more effective treatments for complications of pregnancy associated with altered placental development. Here, we review the maternal growth factors required for placental development and discuss their mechanism of action. {\circledC} 2010 Society for Endocrinology.",
author = "Karen Forbes and Melissa Westwood",
year = "2010",
month = "10",
doi = "10.1677/JOE-10-0174",
language = "English",
volume = "207",
pages = "1--16",
journal = "Journal of Endocrinology",
issn = "0022-0795",
publisher = "BioScientifica",
number = "1",

}

RIS

TY - JOUR

T1 - Maternal growth factor regulation of human placental development and fetal growth

AU - Forbes, Karen

AU - Westwood, Melissa

PY - 2010/10

Y1 - 2010/10

N2 - Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development and function. Although these factors act via distinct receptors to exert their effects, the downstream molecules activated upon ligand/receptor interaction are common to many growth factors. The expression of numerous signaling molecules is altered in the placentas from pregnancies affected by the fetal growth complications, fetal growth restriction, and macrosomia. Thus, targeting these molecules may lead to more effective treatments for complications of pregnancy associated with altered placental development. Here, we review the maternal growth factors required for placental development and discuss their mechanism of action. © 2010 Society for Endocrinology.

AB - Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development and function. Although these factors act via distinct receptors to exert their effects, the downstream molecules activated upon ligand/receptor interaction are common to many growth factors. The expression of numerous signaling molecules is altered in the placentas from pregnancies affected by the fetal growth complications, fetal growth restriction, and macrosomia. Thus, targeting these molecules may lead to more effective treatments for complications of pregnancy associated with altered placental development. Here, we review the maternal growth factors required for placental development and discuss their mechanism of action. © 2010 Society for Endocrinology.

U2 - 10.1677/JOE-10-0174

DO - 10.1677/JOE-10-0174

M3 - Article

VL - 207

SP - 1

EP - 16

JO - Journal of Endocrinology

JF - Journal of Endocrinology

SN - 0022-0795

IS - 1

ER -