Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopyCitation formats

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Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy. / Akhtar, R; Watson, REB; Sherratt, MJ; Kundu, T; Derby, B.

In: Mater Res Soc Symp Proc Mater Res Soc, Vol. 1132E( 1132-Z03-07), No. 1132-Z03-07, 2009.

Research output: Contribution to journalArticle

Harvard

Akhtar, R, Watson, REB, Sherratt, MJ, Kundu, T & Derby, B 2009, 'Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy', Mater Res Soc Symp Proc Mater Res Soc, vol. 1132E( 1132-Z03-07), no. 1132-Z03-07. https://doi.org/10.1557/PROC-1132-Z03-07

APA

Akhtar, R., Watson, REB., Sherratt, MJ., Kundu, T., & Derby, B. (2009). Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy. Mater Res Soc Symp Proc Mater Res Soc, 1132E( 1132-Z03-07)(1132-Z03-07). https://doi.org/10.1557/PROC-1132-Z03-07

Vancouver

Author

Akhtar, R ; Watson, REB ; Sherratt, MJ ; Kundu, T ; Derby, B. / Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy. In: Mater Res Soc Symp Proc Mater Res Soc. 2009 ; Vol. 1132E( 1132-Z03-07), No. 1132-Z03-07.

Bibtex

@article{9f8deb475a4c434f8f8c34cc27959044,
title = "Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy",
abstract = "Although the gross mechanical properties of ageing tissues have been extensively documented, biological tissues are highly heterogeneous and little is known concerning the variation of micro-mechanical properties within tissues. Here, we use Scanning Acoustic Microscopy (SAM) to map the acoustic wave speed (a measure of stiffness) as a function of distance from the outer adventitial layer of cryo-sectioned ferret aorta. With a 400 MHz lens, the images of the aorta samples matched those obtained following chemical fixation and staining of sections which were viewed with fluorescence microscopy. Quantitative analysis was conducted with a frequency scanning or V(f) technique by imaging the tissue from 960 MHz to 1.1 GHz. Undulating acoustic wave speed (stiffness) distributions corresponded with elastic fibre locations in the tissue; there was a decrease in wave speed of around 40 ms(-1) from the adventitia (outer layer) to the intima (innermost).",
author = "R Akhtar and REB Watson and MJ Sherratt and T Kundu and B Derby",
year = "2009",
doi = "10.1557/PROC-1132-Z03-07",
language = "English",
volume = "1132E( 1132-Z03-07)",
journal = "Materials Research Society Symposium Proceedings",
issn = "0272-9172",
publisher = "Materials Research Society",
number = "1132-Z03-07",

}

RIS

TY - JOUR

T1 - Mapping the micromechanical properties of cryo-sectioned aortic tissue with scanning acoustic microscopy

AU - Akhtar, R

AU - Watson, REB

AU - Sherratt, MJ

AU - Kundu, T

AU - Derby, B

PY - 2009

Y1 - 2009

N2 - Although the gross mechanical properties of ageing tissues have been extensively documented, biological tissues are highly heterogeneous and little is known concerning the variation of micro-mechanical properties within tissues. Here, we use Scanning Acoustic Microscopy (SAM) to map the acoustic wave speed (a measure of stiffness) as a function of distance from the outer adventitial layer of cryo-sectioned ferret aorta. With a 400 MHz lens, the images of the aorta samples matched those obtained following chemical fixation and staining of sections which were viewed with fluorescence microscopy. Quantitative analysis was conducted with a frequency scanning or V(f) technique by imaging the tissue from 960 MHz to 1.1 GHz. Undulating acoustic wave speed (stiffness) distributions corresponded with elastic fibre locations in the tissue; there was a decrease in wave speed of around 40 ms(-1) from the adventitia (outer layer) to the intima (innermost).

AB - Although the gross mechanical properties of ageing tissues have been extensively documented, biological tissues are highly heterogeneous and little is known concerning the variation of micro-mechanical properties within tissues. Here, we use Scanning Acoustic Microscopy (SAM) to map the acoustic wave speed (a measure of stiffness) as a function of distance from the outer adventitial layer of cryo-sectioned ferret aorta. With a 400 MHz lens, the images of the aorta samples matched those obtained following chemical fixation and staining of sections which were viewed with fluorescence microscopy. Quantitative analysis was conducted with a frequency scanning or V(f) technique by imaging the tissue from 960 MHz to 1.1 GHz. Undulating acoustic wave speed (stiffness) distributions corresponded with elastic fibre locations in the tissue; there was a decrease in wave speed of around 40 ms(-1) from the adventitia (outer layer) to the intima (innermost).

U2 - 10.1557/PROC-1132-Z03-07

DO - 10.1557/PROC-1132-Z03-07

M3 - Article

VL - 1132E( 1132-Z03-07)

JO - Materials Research Society Symposium Proceedings

JF - Materials Research Society Symposium Proceedings

SN - 0272-9172

IS - 1132-Z03-07

ER -