Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection

Research output: Contribution to journalArticle

  • External authors:
  • Emily C White
  • Ashley Houlden
  • Marie Goldrick


Intestinal dwelling parasites have evolved closely with the complex intestinal microbiota of their host, but the significance of the host microbiota for metazoan pathogens and the role of their own intestinal microbiota are still not fully known. We have found that the parasitic nematodeTrichuris murisacquired a distinct intestinal microbiota from its host, which was required for nematode fitness. Infection of germ-free mice and mice monocolonized withBacteroides thetaiotaomicrondemonstrated that successfulT. murisinfections require a host microbiota. Following infection,T. muris-induced alterations in the host intestinal microbiota inhibited subsequent rounds of infection, controlling parasite numbers within the host intestine. This dual strategy could promote the long-term survival of the parasite within the intestinal niche necessary for successful chronic nematode infection.

Bibliographical metadata

Original languageEnglish
Pages (from-to)eaap7399
JournalScience Advances
Issue number3
Publication statusPublished - 14 Mar 2018

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