Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A “Game Changer” for Prostate Treatment?

Research output: Contribution to journalArticle

  • External authors:
  • Angela U. Pathmanathan
  • Nicholas J. van As
  • Linda G.W. Kerkmeijer
  • John Christodouleas
  • Colleen A.F. Lawton
  • Danny Vesprini
  • Uulke A van der Heide
  • Steven J Frank
  • Simeon Nill
  • Uwe Oelfke
  • X. Allen Li
  • Kathryn Mittauer
  • Mark Ritter
  • Alison C. Tree


Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.

Bibliographical metadata

Original languageEnglish
Pages (from-to)361-373
Number of pages12
JournalInternational Journal of Radiation: Oncology - Biology - Physics
Issue number2
Early online date26 Oct 2017
Publication statusPublished - 1 Feb 2018