Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 PatientsCitation formats

  • External authors:
  • SB Knight
  • FA McClure
  • K Wemyss
  • I Prise
  • L Permain
  • C Jagger
  • DJ Morgan
  • S Khan
  • O Brand
  • A Ustianowski
  • ND Bakerly
  • Christopher E Brightling
  • Seema Brij
  • Timothy Felton
  • Andrew Simpson

Standard

Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients. / Shuwa, HA; Shaw, TN; Knight, SB; McClure, FA; Wemyss, K; Prise, I; Permain, L; Jagger, C; Morgan, DJ; Khan, S; Brand, O; Mann, ER; Ustianowski, A; Bakerly, ND; Menon, M; Dark, Paul; Brightling, Christopher E; Brij, Seema; Felton, Timothy; Simpson, Andrew.

86 p. 2020.

Research output: Other contributionpeer-review

Harvard

Shuwa, HA, Shaw, TN, Knight, SB, McClure, FA, Wemyss, K, Prise, I, Permain, L, Jagger, C, Morgan, DJ, Khan, S, Brand, O, Mann, ER, Ustianowski, A, Bakerly, ND, Menon, M, Dark, P, Brightling, CE, Brij, S, Felton, T & Simpson, A 2020, Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients.. https://doi.org/10.2139/ssrn.3720301

APA

Shuwa, HA., Shaw, TN., Knight, SB., McClure, FA., Wemyss, K., Prise, I., Permain, L., Jagger, C., Morgan, DJ., Khan, S., Brand, O., Mann, ER., Ustianowski, A., Bakerly, ND., Menon, M., Dark, P., Brightling, C. E., Brij, S., Felton, T., & Simpson, A. (2020, Oct 1). Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients. https://doi.org/10.2139/ssrn.3720301

Vancouver

Author

Shuwa, HA ; Shaw, TN ; Knight, SB ; McClure, FA ; Wemyss, K ; Prise, I ; Permain, L ; Jagger, C ; Morgan, DJ ; Khan, S ; Brand, O ; Mann, ER ; Ustianowski, A ; Bakerly, ND ; Menon, M ; Dark, Paul ; Brightling, Christopher E ; Brij, Seema ; Felton, Timothy ; Simpson, Andrew. / Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients. 2020. 86 p.

Bibtex

@misc{4c8fcdb37d674eceb2e75b8bc999ebb7,
title = "Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients",
abstract = "Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Here we describe the phenotypic and functional characteristics of B and T cells in healthy individuals and individuals with acute or convalescent COVID-19. We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed long-term alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/ IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-10+ B cells was restored in a subset of convalescent patients, IL-6 production remained elevated. Our data are the first to define long-term alterations in the lymphocyte compartment of previously hospitalized COVID-19 patients, at up to 19 weeks of convalescence, and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact long-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.",
author = "HA Shuwa and TN Shaw and SB Knight and FA McClure and K Wemyss and I Prise and L Permain and C Jagger and DJ Morgan and S Khan and O Brand and ER Mann and A Ustianowski and ND Bakerly and M Menon and Paul Dark and Brightling, {Christopher E} and Seema Brij and Timothy Felton and Andrew Simpson",
year = "2020",
month = oct,
day = "1",
doi = "10.2139/ssrn.3720301",
language = "English",
type = "Other",

}

RIS

TY - GEN

T1 - Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients

AU - Shuwa, HA

AU - Shaw, TN

AU - Knight, SB

AU - McClure, FA

AU - Wemyss, K

AU - Prise, I

AU - Permain, L

AU - Jagger, C

AU - Morgan, DJ

AU - Khan, S

AU - Brand, O

AU - Mann, ER

AU - Ustianowski, A

AU - Bakerly, ND

AU - Menon, M

AU - Dark, Paul

AU - Brightling, Christopher E

AU - Brij, Seema

AU - Felton, Timothy

AU - Simpson, Andrew

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Here we describe the phenotypic and functional characteristics of B and T cells in healthy individuals and individuals with acute or convalescent COVID-19. We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed long-term alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/ IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-10+ B cells was restored in a subset of convalescent patients, IL-6 production remained elevated. Our data are the first to define long-term alterations in the lymphocyte compartment of previously hospitalized COVID-19 patients, at up to 19 weeks of convalescence, and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact long-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.

AB - Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Here we describe the phenotypic and functional characteristics of B and T cells in healthy individuals and individuals with acute or convalescent COVID-19. We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed long-term alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/ IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-10+ B cells was restored in a subset of convalescent patients, IL-6 production remained elevated. Our data are the first to define long-term alterations in the lymphocyte compartment of previously hospitalized COVID-19 patients, at up to 19 weeks of convalescence, and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact long-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.

UR - http://europepmc.org/abstract/PPR/PPR241719

U2 - 10.2139/ssrn.3720301

DO - 10.2139/ssrn.3720301

M3 - Other contribution

ER -