Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liverCitation formats

  • External authors:
  • Carlos M Minutti
  • Lucy H Jackson-Jones
  • Belen Garcia-Fojeda
  • Johanna A Knipper
  • Nicola Logan
  • Emma Rinqvist
  • Raquel Guillamat-Prats
  • David A Ferenbach
  • Antonio Artigas
  • Cordula Stamme
  • Zissis C Chroneos
  • Dietmar M Zaiss
  • Cristina Casals

Standard

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. / Minutti, Carlos M; Jackson-Jones, Lucy H; Garcia-Fojeda, Belen; Knipper, Johanna A; Sutherland, Tara; Logan, Nicola; Rinqvist, Emma; Guillamat-Prats, Raquel; Ferenbach, David A; Artigas, Antonio; Stamme, Cordula; Chroneos, Zissis C; Zaiss, Dietmar M; Casals, Cristina; Allen, Judith.

In: Science, Vol. 356, 2017.

Research output: Contribution to journalArticle

Harvard

Minutti, CM, Jackson-Jones, LH, Garcia-Fojeda, B, Knipper, JA, Sutherland, T, Logan, N, Rinqvist, E, Guillamat-Prats, R, Ferenbach, DA, Artigas, A, Stamme, C, Chroneos, ZC, Zaiss, DM, Casals, C & Allen, J 2017, 'Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver', Science, vol. 356. https://doi.org/10.1126/science.aaj2067

APA

Vancouver

Author

Minutti, Carlos M ; Jackson-Jones, Lucy H ; Garcia-Fojeda, Belen ; Knipper, Johanna A ; Sutherland, Tara ; Logan, Nicola ; Rinqvist, Emma ; Guillamat-Prats, Raquel ; Ferenbach, David A ; Artigas, Antonio ; Stamme, Cordula ; Chroneos, Zissis C ; Zaiss, Dietmar M ; Casals, Cristina ; Allen, Judith. / Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. In: Science. 2017 ; Vol. 356.

Bibtex

@article{1557c1eb4fbb4a0e85c085b73a645665,
title = "Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver",
abstract = "The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.",
author = "Minutti, {Carlos M} and Jackson-Jones, {Lucy H} and Belen Garcia-Fojeda and Knipper, {Johanna A} and Tara Sutherland and Nicola Logan and Emma Rinqvist and Raquel Guillamat-Prats and Ferenbach, {David A} and Antonio Artigas and Cordula Stamme and Chroneos, {Zissis C} and Zaiss, {Dietmar M} and Cristina Casals and Judith Allen",
year = "2017",
doi = "10.1126/science.aaj2067",
language = "English",
volume = "356",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science (A A A S)",

}

RIS

TY - JOUR

T1 - Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

AU - Minutti, Carlos M

AU - Jackson-Jones, Lucy H

AU - Garcia-Fojeda, Belen

AU - Knipper, Johanna A

AU - Sutherland, Tara

AU - Logan, Nicola

AU - Rinqvist, Emma

AU - Guillamat-Prats, Raquel

AU - Ferenbach, David A

AU - Artigas, Antonio

AU - Stamme, Cordula

AU - Chroneos, Zissis C

AU - Zaiss, Dietmar M

AU - Casals, Cristina

AU - Allen, Judith

PY - 2017

Y1 - 2017

N2 - The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.

AB - The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.

U2 - 10.1126/science.aaj2067

DO - 10.1126/science.aaj2067

M3 - Article

VL - 356

JO - Science

T2 - Science

JF - Science

SN - 0036-8075

ER -