Liver X receptor β:Citation formats

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Liver X receptor β: maintenance of epidermal expression in intrinsic and extrinsic skin aging. / Ford, CT; Sherratt, MJ; Griffiths, CE; Watson, RE.

In: Age, Vol. 31, No. 4, 12.2009, p. 365-372.

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@article{f769fa865dba4bf0bab2c94ca993a3b5,
title = "Liver X receptor β:: maintenance of epidermal expression in intrinsic and extrinsic skin aging",
abstract = "Aging in human skin is the composite of time-dependent intrinsic aging plus photoaging induced by chronic exposure to ultraviolet radiation. Nuclear hormone receptors coordinate diverse processes including metabolic homeostasis. Liver X receptor β (LXRβ) is a close human homologue of daf-12, a regulator of nematode longevity. LXRβ is positively regulated by sirtuin-1 and resveratrol, while LXRβ-null mice show transcriptional profiles similar to those seen in aged human skin. In these studies, we examined LXRβ expression in aged and photoaged human skin. Volunteers were recruited to assess intrinsic aging and photoaging. Epidermal LXRβ mRNA was examined by in situ hybridization while protein was identified by immunofluorescence. No significant changes were observed in either LXRβ mRNA or protein expression between young and aged volunteers (mRNA p=0.90; protein p=0.26). Similarly, LXRβ protein expression was unaltered in photoaged skin (p=0.75). Our data therefore suggest that, while not playing a major role in skin aging, robust cutaneous expression implies a fundamental role for LXRβ in epidermal biology. {\textcopyright} 2009 American Aging Association, Media, PA, USA.",
keywords = "Aging, Liver X receptor, Nuclear hormone receptors, Skin",
author = "CT Ford and MJ Sherratt and CE Griffiths and RE Watson",
year = "2009",
month = dec,
doi = "10.1007/s11357-009-9111-6",
language = "English",
volume = "31",
pages = "365--372",
journal = "Age (Dordrecht, Print)",
issn = "0161-9152",
publisher = "Springer Nature",
number = "4",

}

RIS

TY - JOUR

T1 - Liver X receptor β:

T2 - maintenance of epidermal expression in intrinsic and extrinsic skin aging

AU - Ford, CT

AU - Sherratt, MJ

AU - Griffiths, CE

AU - Watson, RE

PY - 2009/12

Y1 - 2009/12

N2 - Aging in human skin is the composite of time-dependent intrinsic aging plus photoaging induced by chronic exposure to ultraviolet radiation. Nuclear hormone receptors coordinate diverse processes including metabolic homeostasis. Liver X receptor β (LXRβ) is a close human homologue of daf-12, a regulator of nematode longevity. LXRβ is positively regulated by sirtuin-1 and resveratrol, while LXRβ-null mice show transcriptional profiles similar to those seen in aged human skin. In these studies, we examined LXRβ expression in aged and photoaged human skin. Volunteers were recruited to assess intrinsic aging and photoaging. Epidermal LXRβ mRNA was examined by in situ hybridization while protein was identified by immunofluorescence. No significant changes were observed in either LXRβ mRNA or protein expression between young and aged volunteers (mRNA p=0.90; protein p=0.26). Similarly, LXRβ protein expression was unaltered in photoaged skin (p=0.75). Our data therefore suggest that, while not playing a major role in skin aging, robust cutaneous expression implies a fundamental role for LXRβ in epidermal biology. © 2009 American Aging Association, Media, PA, USA.

AB - Aging in human skin is the composite of time-dependent intrinsic aging plus photoaging induced by chronic exposure to ultraviolet radiation. Nuclear hormone receptors coordinate diverse processes including metabolic homeostasis. Liver X receptor β (LXRβ) is a close human homologue of daf-12, a regulator of nematode longevity. LXRβ is positively regulated by sirtuin-1 and resveratrol, while LXRβ-null mice show transcriptional profiles similar to those seen in aged human skin. In these studies, we examined LXRβ expression in aged and photoaged human skin. Volunteers were recruited to assess intrinsic aging and photoaging. Epidermal LXRβ mRNA was examined by in situ hybridization while protein was identified by immunofluorescence. No significant changes were observed in either LXRβ mRNA or protein expression between young and aged volunteers (mRNA p=0.90; protein p=0.26). Similarly, LXRβ protein expression was unaltered in photoaged skin (p=0.75). Our data therefore suggest that, while not playing a major role in skin aging, robust cutaneous expression implies a fundamental role for LXRβ in epidermal biology. © 2009 American Aging Association, Media, PA, USA.

KW - Aging

KW - Liver X receptor

KW - Nuclear hormone receptors

KW - Skin

UR - http://europepmc.org/abstract/med/19697157

U2 - 10.1007/s11357-009-9111-6

DO - 10.1007/s11357-009-9111-6

M3 - Article

C2 - 19697157

VL - 31

SP - 365

EP - 372

JO - Age (Dordrecht, Print)

JF - Age (Dordrecht, Print)

SN - 0161-9152

IS - 4

ER -