Limitations of microbial iron reduction under extreme conditionsCitation formats

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Limitations of microbial iron reduction under extreme conditions. / Nixon, Sophie; Bonsall, Emily; Cockell, Charles S.

In: FEMS microbiology reviews, 27.06.2022.

Research output: Contribution to journalArticlepeer-review

Harvard

Nixon, S, Bonsall, E & Cockell, CS 2022, 'Limitations of microbial iron reduction under extreme conditions', FEMS microbiology reviews.

APA

Nixon, S., Bonsall, E., & Cockell, C. S. (Accepted/In press). Limitations of microbial iron reduction under extreme conditions. FEMS microbiology reviews.

Vancouver

Nixon S, Bonsall E, Cockell CS. Limitations of microbial iron reduction under extreme conditions. FEMS microbiology reviews. 2022 Jun 27.

Author

Nixon, Sophie ; Bonsall, Emily ; Cockell, Charles S. / Limitations of microbial iron reduction under extreme conditions. In: FEMS microbiology reviews. 2022.

Bibtex

@article{d627d19d1a7f48d0b0ab169ad7d120b5,
title = "Limitations of microbial iron reduction under extreme conditions",
abstract = "Microbial iron reduction is a widespread and ancient metabolism on Earth, and may plausibly support microbial life on Mars and beyond. Yet the extreme limits of this metabolism are yet to be defined. To investigate this, we surveyed the recorded limits to microbial iron reduction in a wide range of characterised iron-reducing microorganisms (n=141), with a focus on pH and temperature. We then calculated Gibbs free energy of common microbially-mediated iron reduction reactions across the pH-temperature habitability space to identify thermodynamic limits. Comparing predicted and observed limits, we show that microbial iron reduction is generally reported at extremes of pH or temperature alone, but not when these extremes are combined (with the exception of a small number of acidophilic hyperthermophiles). These patterns leave thermodynamically favourable combinations of pH and temperature apparently unoccupied. The empty spaces could be explained by experimental bias, but they could also be explained by energetic and biochemical limits to iron reduction at combined extremes. Our data allow for a review of our current understanding of the limits to microbial iron reduction at extremes and provide a basis to test more general hypotheses about the extent to which biochemistry establishes the limits to life.",
author = "Sophie Nixon and Emily Bonsall and Cockell, {Charles S.}",
year = "2022",
month = jun,
day = "27",
language = "English",
journal = "FEMS microbiology reviews",
issn = "0168-6445",
publisher = "John Wiley & Sons Ltd",

}

RIS

TY - JOUR

T1 - Limitations of microbial iron reduction under extreme conditions

AU - Nixon, Sophie

AU - Bonsall, Emily

AU - Cockell, Charles S.

PY - 2022/6/27

Y1 - 2022/6/27

N2 - Microbial iron reduction is a widespread and ancient metabolism on Earth, and may plausibly support microbial life on Mars and beyond. Yet the extreme limits of this metabolism are yet to be defined. To investigate this, we surveyed the recorded limits to microbial iron reduction in a wide range of characterised iron-reducing microorganisms (n=141), with a focus on pH and temperature. We then calculated Gibbs free energy of common microbially-mediated iron reduction reactions across the pH-temperature habitability space to identify thermodynamic limits. Comparing predicted and observed limits, we show that microbial iron reduction is generally reported at extremes of pH or temperature alone, but not when these extremes are combined (with the exception of a small number of acidophilic hyperthermophiles). These patterns leave thermodynamically favourable combinations of pH and temperature apparently unoccupied. The empty spaces could be explained by experimental bias, but they could also be explained by energetic and biochemical limits to iron reduction at combined extremes. Our data allow for a review of our current understanding of the limits to microbial iron reduction at extremes and provide a basis to test more general hypotheses about the extent to which biochemistry establishes the limits to life.

AB - Microbial iron reduction is a widespread and ancient metabolism on Earth, and may plausibly support microbial life on Mars and beyond. Yet the extreme limits of this metabolism are yet to be defined. To investigate this, we surveyed the recorded limits to microbial iron reduction in a wide range of characterised iron-reducing microorganisms (n=141), with a focus on pH and temperature. We then calculated Gibbs free energy of common microbially-mediated iron reduction reactions across the pH-temperature habitability space to identify thermodynamic limits. Comparing predicted and observed limits, we show that microbial iron reduction is generally reported at extremes of pH or temperature alone, but not when these extremes are combined (with the exception of a small number of acidophilic hyperthermophiles). These patterns leave thermodynamically favourable combinations of pH and temperature apparently unoccupied. The empty spaces could be explained by experimental bias, but they could also be explained by energetic and biochemical limits to iron reduction at combined extremes. Our data allow for a review of our current understanding of the limits to microbial iron reduction at extremes and provide a basis to test more general hypotheses about the extent to which biochemistry establishes the limits to life.

M3 - Article

JO - FEMS microbiology reviews

JF - FEMS microbiology reviews

SN - 0168-6445

ER -