Kidney exchange strategies: new aspects and applications with a focus on deceased donor-initiated chains

Research output: Contribution to journalReview articlepeer-review

  • External authors:
  • Lucrezia Furian
  • Caterina Di Bella
  • Massimo Cardillo
  • Emanuele Cozzi
  • Paolo Rigotti

Abstract

Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus on advanced KPD strategies, including the most recent idea of initiating living donor (LD) transplantation chains with a deceased donor (DD) kidney, first applied successfully in 2018. Since then, Italy has been running a national programme in which a chain-initiating kidney is selected from a DD pool and allocated to a recipient with an incompatible LD, and the LD’s kidney is transplanted into a patient on the waiting list (WL). At this stage, since the ethical and logistic issues have been managed appropriately, KPD starting with a DD has proved to be a feasible strategy. It enables transplants in recipients of incompatible pairs without the need for desensitizing and also benefits patients on the WL who are allocated chain-ending kidneys from LDs (prioritizing sensitized patients and those on the WL for longer).

Bibliographical metadata

Original languageEnglish
Pages (from-to)1177-1184
Number of pages8
JournalTransplant International
Volume33
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020

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