Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermisCitation formats

  • External authors:
  • Kristin Seltmann
  • Andreas Bachmann
  • Andreas Schwendimann
  • Lalitha Thiagarajan
  • Paulina Hennig
  • Hans-Dietmar Beer
  • Maria Rosaria Mollo
  • Caterina Missero
  • Sabine Werner

Standard

Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis. / Kurinna, Svitlana; Seltmann, Kristin; Bachmann, Andreas; Schwendimann, Andreas; Thiagarajan, Lalitha; Hennig, Paulina; Beer, Hans-Dietmar; Mollo, Maria Rosaria; Missero, Caterina; Werner, Sabine.

In: Nucleic Acids Res, 01.03.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Kurinna, S, Seltmann, K, Bachmann, A, Schwendimann, A, Thiagarajan, L, Hennig, P, Beer, H-D, Mollo, MR, Missero, C & Werner, S 2021, 'Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis', Nucleic Acids Res.

APA

Kurinna, S., Seltmann, K., Bachmann, A., Schwendimann, A., Thiagarajan, L., Hennig, P., Beer, H-D., Mollo, M. R., Missero, C., & Werner, S. (Accepted/In press). Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis. Nucleic Acids Res.

Vancouver

Kurinna S, Seltmann K, Bachmann A, Schwendimann A, Thiagarajan L, Hennig P et al. Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis. Nucleic Acids Res. 2021 Mar 1.

Author

Kurinna, Svitlana ; Seltmann, Kristin ; Bachmann, Andreas ; Schwendimann, Andreas ; Thiagarajan, Lalitha ; Hennig, Paulina ; Beer, Hans-Dietmar ; Mollo, Maria Rosaria ; Missero, Caterina ; Werner, Sabine. / Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis. In: Nucleic Acids Res. 2021.

Bibtex

@article{e31dae0ac6914c80bbd7b5fb1fd58beb,
title = "Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis",
abstract = "Epigenetic regulation of cell and tissue function requires the coordinated action of transcription factors. However, their combinatorial activities during regeneration remain largely unexplored. Here we discover an unexpected interaction between the cytoprotective transcription factor NRF2 and p63, a key player in epithelial morphogenesis. Chromatin immunoprecipitation combined with sequencing and reporter assays identifies enhancers and promoters that are simultaneously activated by NRF2 and p63 in human keratinocytes. Modeling of p63 and NRF2 binding to nucleosomal DNA suggests their chromatin-assisted interaction. Pharmacological and genetic activation of NRF2 increases NRF2-p63 binding to enhancers and promotes keratinocyte proliferation, which involves the common NRF2-p63 target cyclin-dependent kinase 12. These results unravel a collaborative function of NRF2 and p63 in the control of epidermal renewal and suggest their combined activation as a strategy to promote repair of human skin and other stratified epithelia.",
author = "Svitlana Kurinna and Kristin Seltmann and Andreas Bachmann and Andreas Schwendimann and Lalitha Thiagarajan and Paulina Hennig and Hans-Dietmar Beer and Mollo, {Maria Rosaria} and Caterina Missero and Sabine Werner",
year = "2021",
month = mar,
day = "1",
language = "English",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Interaction of the NRF2 and p63 transcription factors promotes keratinocyte proliferation in the epidermis

AU - Kurinna, Svitlana

AU - Seltmann, Kristin

AU - Bachmann, Andreas

AU - Schwendimann, Andreas

AU - Thiagarajan, Lalitha

AU - Hennig, Paulina

AU - Beer, Hans-Dietmar

AU - Mollo, Maria Rosaria

AU - Missero, Caterina

AU - Werner, Sabine

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Epigenetic regulation of cell and tissue function requires the coordinated action of transcription factors. However, their combinatorial activities during regeneration remain largely unexplored. Here we discover an unexpected interaction between the cytoprotective transcription factor NRF2 and p63, a key player in epithelial morphogenesis. Chromatin immunoprecipitation combined with sequencing and reporter assays identifies enhancers and promoters that are simultaneously activated by NRF2 and p63 in human keratinocytes. Modeling of p63 and NRF2 binding to nucleosomal DNA suggests their chromatin-assisted interaction. Pharmacological and genetic activation of NRF2 increases NRF2-p63 binding to enhancers and promotes keratinocyte proliferation, which involves the common NRF2-p63 target cyclin-dependent kinase 12. These results unravel a collaborative function of NRF2 and p63 in the control of epidermal renewal and suggest their combined activation as a strategy to promote repair of human skin and other stratified epithelia.

AB - Epigenetic regulation of cell and tissue function requires the coordinated action of transcription factors. However, their combinatorial activities during regeneration remain largely unexplored. Here we discover an unexpected interaction between the cytoprotective transcription factor NRF2 and p63, a key player in epithelial morphogenesis. Chromatin immunoprecipitation combined with sequencing and reporter assays identifies enhancers and promoters that are simultaneously activated by NRF2 and p63 in human keratinocytes. Modeling of p63 and NRF2 binding to nucleosomal DNA suggests their chromatin-assisted interaction. Pharmacological and genetic activation of NRF2 increases NRF2-p63 binding to enhancers and promotes keratinocyte proliferation, which involves the common NRF2-p63 target cyclin-dependent kinase 12. These results unravel a collaborative function of NRF2 and p63 in the control of epidermal renewal and suggest their combined activation as a strategy to promote repair of human skin and other stratified epithelia.

M3 - Article

JO - Nucleic acids research

JF - Nucleic acids research

SN - 0305-1048

ER -