An integrated cleaner biocatalyst process is performed for biodiesel production from crude palm oil (CPO) and refined palm oil (RPO). It was evaluated on process efficiency in terms of high pu-rity of biodiesel as well as by-product without purification, less wastewater, less time consum-ing and simple downstream process. A first saponification step was carried out in both of CPO and RPO, a high purity of glycerol (86.25% and 87.5%) was achieved, respectively, while, free fatty acids (FFASs) in soap were obtained after hexane extraction. High yields of FFASs were obtained from both CPO and RPO (98.83% and 90.94%). Subsequently, the FFAs were esterified to biodiesel by a biocatalyst of immobilised lipase. The highest biodiesel yields of 92.14% and 92.58% (CPO and RPO) were achieved. Remarkably, biodiesel yields obtained from CPO and RPO could reach satisfied values as well as a biocatalyst used could reuse much more than 16-17 cycles.