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InspIRED by Nature : NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines. / Grogan, Gideon; Turner, Nicholas.

In: Chemistry - A European Journal, Vol. 22, No. 6, 05.02.2016, p. 1900-1907.

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Grogan, Gideon ; Turner, Nicholas. / InspIRED by Nature : NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines. In: Chemistry - A European Journal. 2016 ; Vol. 22, No. 6. pp. 1900-1907.

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@article{fe9b1306fee94c5eb088a47d42578339,
title = "InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines",
abstract = "Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. Since their discovery, stereocomplementary IREDs have been applied to the production of both (S) and (R) cyclic secondary amines, and the expansion in gene sequences recently identified has hinted at new substrate ranges that extend into acyclic imines and even suggest the possibility of asymmetric reductive amination from suitable ketone and amine precursors. Structural studies of various IREDs are beginning to reveal the complexities inherent in determining substrate range, stereoselectivity and mechanism in these enzymes, which represent a valuable emerging addition to the toolbox of available biocatalysts for chiral amine production. Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. The recent identification of the first IREDs has led to a rapid growth in research in this area and many studies on the application, structure and mechanism of the enzymes reveal IREDs to be a valuable addition to the toolbox of biocatalysts for chiral amine production.",
keywords = "amines, biocatalysis, NADPH, oxidoreductases, stereoselectivity",
author = "Gideon Grogan and Nicholas Turner",
year = "2016",
month = "2",
day = "5",
doi = "10.1002/chem.201503954",
language = "English",
volume = "22",
pages = "1900--1907",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "John Wiley & Sons Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - InspIRED by Nature

T2 - NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

AU - Grogan, Gideon

AU - Turner, Nicholas

PY - 2016/2/5

Y1 - 2016/2/5

N2 - Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. Since their discovery, stereocomplementary IREDs have been applied to the production of both (S) and (R) cyclic secondary amines, and the expansion in gene sequences recently identified has hinted at new substrate ranges that extend into acyclic imines and even suggest the possibility of asymmetric reductive amination from suitable ketone and amine precursors. Structural studies of various IREDs are beginning to reveal the complexities inherent in determining substrate range, stereoselectivity and mechanism in these enzymes, which represent a valuable emerging addition to the toolbox of available biocatalysts for chiral amine production. Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. The recent identification of the first IREDs has led to a rapid growth in research in this area and many studies on the application, structure and mechanism of the enzymes reveal IREDs to be a valuable addition to the toolbox of biocatalysts for chiral amine production.

AB - Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. Since their discovery, stereocomplementary IREDs have been applied to the production of both (S) and (R) cyclic secondary amines, and the expansion in gene sequences recently identified has hinted at new substrate ranges that extend into acyclic imines and even suggest the possibility of asymmetric reductive amination from suitable ketone and amine precursors. Structural studies of various IREDs are beginning to reveal the complexities inherent in determining substrate range, stereoselectivity and mechanism in these enzymes, which represent a valuable emerging addition to the toolbox of available biocatalysts for chiral amine production. Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. The recent identification of the first IREDs has led to a rapid growth in research in this area and many studies on the application, structure and mechanism of the enzymes reveal IREDs to be a valuable addition to the toolbox of biocatalysts for chiral amine production.

KW - amines

KW - biocatalysis

KW - NADPH

KW - oxidoreductases

KW - stereoselectivity

UR - http://www.scopus.com/inward/record.url?scp=84956817241&partnerID=8YFLogxK

U2 - 10.1002/chem.201503954

DO - 10.1002/chem.201503954

M3 - Article

VL - 22

SP - 1900

EP - 1907

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 6

ER -