In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography

Research output: Contribution to journalArticle

  • External authors:
  • Paul Cernohorsky
  • Daniel M de Bruin
  • Johannes Bras
  • Dirk J Faber
  • Simon D Strackee
  • Ton G van Leeuwen

Abstract

Conventional imaging modalities are unable to depict the early degeneration of articular cartilage in osteoarthritis, especially in small joints. Optical coherence tomography has previously been used successfully in high-resolution imaging of cartilage tissue. This pilot cadaver study demonstrates the use of intra-articular optical coherence tomography in imaging of articular cartilage of the first carpometacarpal joint, producing high resolution images of the articular surface in which cartilage thickness and surface characteristics were assessed. Findings on optical coherence tomography were confirmed with histology. Furthermore, co-registration of optical coherence tomography and computed tomography was used to accurately determine the scanned trajectory and reconstruct a true-scale image overlay.

Bibliographical metadata

Original languageEnglish
Pages (from-to)060501
JournalJournal of Biomedical Optics
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 2012