Insertion of arynes into thioureas: A new amidine synthesis

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Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and represents a new, operationally simple route to functionalized amidines. © 2011 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4946-4949
Number of pages3
JournalOrganic Letters
Issue number18
StatePublished - 16 Sep 2011