We present an investigation of inkjet printed strain gauges based on two-dimensional (2D) materials. The technology leverages water-based and biocompatible inks to fabricate strain measurement devices on flexible substrates such as paper. We demonstrate that the device performance and sensitivity are strongly dependent on the printing parameter (i.e., drop-spacing, number of printing passes, etc.). We show that values of the Gauge Factor up to 125 can be obtained, with large sensitivity (>20%) even when small strains (0.3%) are applied. Furthermore, we provide preliminary examples of heterostructure-based strain sensors, enabled by the inkjet printing technology.