Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicityCitation formats

  • External authors:
  • Gillian C. Barnett
  • Rebecca M. Elliott
  • Jan Alsner
  • Christian N. Andreassen
  • Osama Abdelhay
  • Neil G. Burnet
  • Jenny Chang-Claude
  • Charlotte E. Coles
  • Sara Gutiérrez-Enríquez
  • Maria J. Fuentes-Raspall
  • Maria C. Alonso-Muñoz
  • Sarah Kerns
  • Annette Raabe
  • R. Paul Symonds
  • Petra Seibold
  • Chris J. Talbot
  • Frederik Wenz
  • Jennifer Wilkinson
  • John Yarnold
  • Alison M. Dunning
  • Barry S. Rosenstein
  • Soren M. Bentzen

Standard

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. / Barnett, Gillian C.; Elliott, Rebecca M.; Alsner, Jan; Andreassen, Christian N.; Abdelhay, Osama; Burnet, Neil G.; Chang-Claude, Jenny; Coles, Charlotte E.; Gutiérrez-Enríquez, Sara; Fuentes-Raspall, Maria J.; Alonso-Muñoz, Maria C.; Kerns, Sarah; Raabe, Annette; Symonds, R. Paul; Seibold, Petra; Talbot, Chris J.; Wenz, Frederik; Wilkinson, Jennifer; Yarnold, John; Dunning, Alison M.; Rosenstein, Barry S.; West, Catharine M L; Bentzen, Soren M.

In: Radiotherapy and Oncology, Vol. 105, No. 3, 12.2012, p. 289-295.

Research output: Contribution to journalArticle

Harvard

Barnett, GC, Elliott, RM, Alsner, J, Andreassen, CN, Abdelhay, O, Burnet, NG, Chang-Claude, J, Coles, CE, Gutiérrez-Enríquez, S, Fuentes-Raspall, MJ, Alonso-Muñoz, MC, Kerns, S, Raabe, A, Symonds, RP, Seibold, P, Talbot, CJ, Wenz, F, Wilkinson, J, Yarnold, J, Dunning, AM, Rosenstein, BS, West, CML & Bentzen, SM 2012, 'Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity', Radiotherapy and Oncology, vol. 105, no. 3, pp. 289-295. https://doi.org/10.1016/j.radonc.2012.10.017

APA

Barnett, G. C., Elliott, R. M., Alsner, J., Andreassen, C. N., Abdelhay, O., Burnet, N. G., ... Bentzen, S. M. (2012). Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiotherapy and Oncology, 105(3), 289-295. https://doi.org/10.1016/j.radonc.2012.10.017

Vancouver

Barnett GC, Elliott RM, Alsner J, Andreassen CN, Abdelhay O, Burnet NG et al. Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. Radiotherapy and Oncology. 2012 Dec;105(3):289-295. https://doi.org/10.1016/j.radonc.2012.10.017

Author

Barnett, Gillian C. ; Elliott, Rebecca M. ; Alsner, Jan ; Andreassen, Christian N. ; Abdelhay, Osama ; Burnet, Neil G. ; Chang-Claude, Jenny ; Coles, Charlotte E. ; Gutiérrez-Enríquez, Sara ; Fuentes-Raspall, Maria J. ; Alonso-Muñoz, Maria C. ; Kerns, Sarah ; Raabe, Annette ; Symonds, R. Paul ; Seibold, Petra ; Talbot, Chris J. ; Wenz, Frederik ; Wilkinson, Jennifer ; Yarnold, John ; Dunning, Alison M. ; Rosenstein, Barry S. ; West, Catharine M L ; Bentzen, Soren M. / Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity. In: Radiotherapy and Oncology. 2012 ; Vol. 105, No. 3. pp. 289-295.

Bibtex

@article{9069b13d175f4602bc00ad6192bda025,
title = "Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity",
abstract = "Background and purpose: Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-β1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies. Materials and methods: TGFB1 SNP rs1800469 c.-1347T>C (previously known as C-509T) genotype, treatment-related data, and clinically-assessed fibrosis (measured at least 2 years after therapy) were available in 2782 participants from 11 cohorts. All received adjuvant breast radiotherapy. Associations between late fibrosis or overall toxicity, reported by STAT (Standardised Total Average Toxicity) score, and rs1800469 genotype were assessed. Results: No statistically significant associations between either fibrosis or overall toxicity and rs1800469 genotype were observed with univariate or multivariate regression analysis. The multivariate odds ratio (OR), obtained from meta-analysis, for an increase in late fibrosis grade with each additional rare allele of rs1800469 was 0.98 (95{\%} Confidence Interval (CI) 0.85-1.11). This CI is sufficiently narrow to rule out any clinically relevant effect on toxicity risk in carriers vs. non-carriers with a high probability. Conclusion: This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients. It has demonstrated successful collaboration within the Radiogenomics Consortium. {\circledC} 2012 Elsevier Ireland Ltd. All rights reserved.",
keywords = "Adverse effects, Meta-analysis, Radiotherapy, Toxicity",
author = "Barnett, {Gillian C.} and Elliott, {Rebecca M.} and Jan Alsner and Andreassen, {Christian N.} and Osama Abdelhay and Burnet, {Neil G.} and Jenny Chang-Claude and Coles, {Charlotte E.} and Sara Guti{\'e}rrez-Enr{\'i}quez and Fuentes-Raspall, {Maria J.} and Alonso-Mu{\~n}oz, {Maria C.} and Sarah Kerns and Annette Raabe and Symonds, {R. Paul} and Petra Seibold and Talbot, {Chris J.} and Frederik Wenz and Jennifer Wilkinson and John Yarnold and Dunning, {Alison M.} and Rosenstein, {Barry S.} and West, {Catharine M L} and Bentzen, {Soren M.}",
note = ", Department of Health, United Kingdom",
year = "2012",
month = "12",
doi = "10.1016/j.radonc.2012.10.017",
language = "English",
volume = "105",
pages = "289--295",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity

AU - Barnett, Gillian C.

AU - Elliott, Rebecca M.

AU - Alsner, Jan

AU - Andreassen, Christian N.

AU - Abdelhay, Osama

AU - Burnet, Neil G.

AU - Chang-Claude, Jenny

AU - Coles, Charlotte E.

AU - Gutiérrez-Enríquez, Sara

AU - Fuentes-Raspall, Maria J.

AU - Alonso-Muñoz, Maria C.

AU - Kerns, Sarah

AU - Raabe, Annette

AU - Symonds, R. Paul

AU - Seibold, Petra

AU - Talbot, Chris J.

AU - Wenz, Frederik

AU - Wilkinson, Jennifer

AU - Yarnold, John

AU - Dunning, Alison M.

AU - Rosenstein, Barry S.

AU - West, Catharine M L

AU - Bentzen, Soren M.

N1 - , Department of Health, United Kingdom

PY - 2012/12

Y1 - 2012/12

N2 - Background and purpose: Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-β1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies. Materials and methods: TGFB1 SNP rs1800469 c.-1347T>C (previously known as C-509T) genotype, treatment-related data, and clinically-assessed fibrosis (measured at least 2 years after therapy) were available in 2782 participants from 11 cohorts. All received adjuvant breast radiotherapy. Associations between late fibrosis or overall toxicity, reported by STAT (Standardised Total Average Toxicity) score, and rs1800469 genotype were assessed. Results: No statistically significant associations between either fibrosis or overall toxicity and rs1800469 genotype were observed with univariate or multivariate regression analysis. The multivariate odds ratio (OR), obtained from meta-analysis, for an increase in late fibrosis grade with each additional rare allele of rs1800469 was 0.98 (95% Confidence Interval (CI) 0.85-1.11). This CI is sufficiently narrow to rule out any clinically relevant effect on toxicity risk in carriers vs. non-carriers with a high probability. Conclusion: This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients. It has demonstrated successful collaboration within the Radiogenomics Consortium. © 2012 Elsevier Ireland Ltd. All rights reserved.

AB - Background and purpose: Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-β1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies. Materials and methods: TGFB1 SNP rs1800469 c.-1347T>C (previously known as C-509T) genotype, treatment-related data, and clinically-assessed fibrosis (measured at least 2 years after therapy) were available in 2782 participants from 11 cohorts. All received adjuvant breast radiotherapy. Associations between late fibrosis or overall toxicity, reported by STAT (Standardised Total Average Toxicity) score, and rs1800469 genotype were assessed. Results: No statistically significant associations between either fibrosis or overall toxicity and rs1800469 genotype were observed with univariate or multivariate regression analysis. The multivariate odds ratio (OR), obtained from meta-analysis, for an increase in late fibrosis grade with each additional rare allele of rs1800469 was 0.98 (95% Confidence Interval (CI) 0.85-1.11). This CI is sufficiently narrow to rule out any clinically relevant effect on toxicity risk in carriers vs. non-carriers with a high probability. Conclusion: This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients. It has demonstrated successful collaboration within the Radiogenomics Consortium. © 2012 Elsevier Ireland Ltd. All rights reserved.

KW - Adverse effects

KW - Meta-analysis

KW - Radiotherapy

KW - Toxicity

U2 - 10.1016/j.radonc.2012.10.017

DO - 10.1016/j.radonc.2012.10.017

M3 - Article

VL - 105

SP - 289

EP - 295

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

IS - 3

ER -