Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patientsCitation formats

  • Authors:
  • Christian Nicolaj Andreassen
  • Barry S Rosenstein
  • Sarah L Kerns
  • Harry Ostrer
  • Dirk De Ruysscher
  • Jamie A Cesaretti
  • Gillian C Barnett
  • Alison M Dunning
  • Leila Dorling
  • Catharine M L West
  • Neil G Burnet
  • Rebecca Elliott
  • Charlotte Coles
  • Emma Hall
  • Laura Fachal
  • Ana Vega
  • Antonio Gómez-Caamaño
  • Christopher J Talbot
  • R Paul Symonds
  • Kim De Ruyck
  • Hubert Thierens
  • Piet Ost
  • Jenny Chang-Claude
  • Petra Seibold
  • Odilia Popanda
  • Marie Overgaard
  • David Dearnaley
  • Matthew R Sydes
  • David Azria
  • Christine Anne Koch
  • Matthew Parliament
  • Michael Blackshaw
  • Michael Sia
  • Maria J Fuentes-Raspall
  • Teresa Ramon Y Cajal
  • Agustin Barnadas
  • Danny Vesprini
  • Sara Gutiérrez-Enríquez
  • Meritxell Mollà
  • Orland Díez
  • John R Yarnold
  • Jens Overgaard
  • Søren M Bentzen
  • Jan Alsner
  • International Radiogenomics Consortium (RgC)

Standard

Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. / Andreassen, Christian Nicolaj; Rosenstein, Barry S; Kerns, Sarah L; Ostrer, Harry; De Ruysscher, Dirk; Cesaretti, Jamie A; Barnett, Gillian C; Dunning, Alison M; Dorling, Leila; West, Catharine M L; Burnet, Neil G; Elliott, Rebecca; Coles, Charlotte; Hall, Emma; Fachal, Laura; Vega, Ana; Gómez-Caamaño, Antonio; Talbot, Christopher J; Symonds, R Paul; De Ruyck, Kim; Thierens, Hubert; Ost, Piet; Chang-Claude, Jenny; Seibold, Petra; Popanda, Odilia; Overgaard, Marie; Dearnaley, David; Sydes, Matthew R; Azria, David; Koch, Christine Anne; Parliament, Matthew; Blackshaw, Michael; Sia, Michael; Fuentes-Raspall, Maria J; Ramon Y Cajal, Teresa; Barnadas, Agustin; Vesprini, Danny; Gutiérrez-Enríquez, Sara; Mollà, Meritxell; Díez, Orland; Yarnold, John R; Overgaard, Jens; Bentzen, Søren M; Alsner, Jan; International Radiogenomics Consortium (RgC).

In: Radiotherapy and Oncology, Vol. 121, No. 3, 12.2016, p. 431-439.

Research output: Contribution to journalArticle

Harvard

Andreassen, CN, Rosenstein, BS, Kerns, SL, Ostrer, H, De Ruysscher, D, Cesaretti, JA, Barnett, GC, Dunning, AM, Dorling, L, West, CML, Burnet, NG, Elliott, R, Coles, C, Hall, E, Fachal, L, Vega, A, Gómez-Caamaño, A, Talbot, CJ, Symonds, RP, De Ruyck, K, Thierens, H, Ost, P, Chang-Claude, J, Seibold, P, Popanda, O, Overgaard, M, Dearnaley, D, Sydes, MR, Azria, D, Koch, CA, Parliament, M, Blackshaw, M, Sia, M, Fuentes-Raspall, MJ, Ramon Y Cajal, T, Barnadas, A, Vesprini, D, Gutiérrez-Enríquez, S, Mollà, M, Díez, O, Yarnold, JR, Overgaard, J, Bentzen, SM, Alsner, J & International Radiogenomics Consortium (RgC) 2016, 'Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients', Radiotherapy and Oncology, vol. 121, no. 3, pp. 431-439. https://doi.org/10.1016/j.radonc.2016.06.017

APA

Andreassen, C. N., Rosenstein, B. S., Kerns, S. L., Ostrer, H., De Ruysscher, D., Cesaretti, J. A., ... International Radiogenomics Consortium (RgC) (2016). Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. Radiotherapy and Oncology, 121(3), 431-439. https://doi.org/10.1016/j.radonc.2016.06.017

Vancouver

Author

Andreassen, Christian Nicolaj ; Rosenstein, Barry S ; Kerns, Sarah L ; Ostrer, Harry ; De Ruysscher, Dirk ; Cesaretti, Jamie A ; Barnett, Gillian C ; Dunning, Alison M ; Dorling, Leila ; West, Catharine M L ; Burnet, Neil G ; Elliott, Rebecca ; Coles, Charlotte ; Hall, Emma ; Fachal, Laura ; Vega, Ana ; Gómez-Caamaño, Antonio ; Talbot, Christopher J ; Symonds, R Paul ; De Ruyck, Kim ; Thierens, Hubert ; Ost, Piet ; Chang-Claude, Jenny ; Seibold, Petra ; Popanda, Odilia ; Overgaard, Marie ; Dearnaley, David ; Sydes, Matthew R ; Azria, David ; Koch, Christine Anne ; Parliament, Matthew ; Blackshaw, Michael ; Sia, Michael ; Fuentes-Raspall, Maria J ; Ramon Y Cajal, Teresa ; Barnadas, Agustin ; Vesprini, Danny ; Gutiérrez-Enríquez, Sara ; Mollà, Meritxell ; Díez, Orland ; Yarnold, John R ; Overgaard, Jens ; Bentzen, Søren M ; Alsner, Jan ; International Radiogenomics Consortium (RgC). / Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. In: Radiotherapy and Oncology. 2016 ; Vol. 121, No. 3. pp. 431-439.

Bibtex

@article{4b812eb695784f25b93f1a70e0dc4594,
title = "Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients",
abstract = "PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.",
keywords = "Alleles, Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genotype, Heterozygote, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Radiation Injuries, Radiation Tolerance, Radiotherapy, Risk Factors, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural",
author = "Andreassen, {Christian Nicolaj} and Rosenstein, {Barry S} and Kerns, {Sarah L} and Harry Ostrer and {De Ruysscher}, Dirk and Cesaretti, {Jamie A} and Barnett, {Gillian C} and Dunning, {Alison M} and Leila Dorling and West, {Catharine M L} and Burnet, {Neil G} and Rebecca Elliott and Charlotte Coles and Emma Hall and Laura Fachal and Ana Vega and Antonio G{\'o}mez-Caama{\~n}o and Talbot, {Christopher J} and Symonds, {R Paul} and {De Ruyck}, Kim and Hubert Thierens and Piet Ost and Jenny Chang-Claude and Petra Seibold and Odilia Popanda and Marie Overgaard and David Dearnaley and Sydes, {Matthew R} and David Azria and Koch, {Christine Anne} and Matthew Parliament and Michael Blackshaw and Michael Sia and Fuentes-Raspall, {Maria J} and {Ramon Y Cajal}, Teresa and Agustin Barnadas and Danny Vesprini and Sara Guti{\'e}rrez-Enr{\'i}quez and Meritxell Moll{\`a} and Orland D{\'i}ez and Yarnold, {John R} and Jens Overgaard and Bentzen, {S{\o}ren M} and Jan Alsner and {International Radiogenomics Consortium (RgC)}",
note = "Copyright {\circledC} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = "12",
doi = "10.1016/j.radonc.2016.06.017",
language = "English",
volume = "121",
pages = "431--439",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

AU - Andreassen, Christian Nicolaj

AU - Rosenstein, Barry S

AU - Kerns, Sarah L

AU - Ostrer, Harry

AU - De Ruysscher, Dirk

AU - Cesaretti, Jamie A

AU - Barnett, Gillian C

AU - Dunning, Alison M

AU - Dorling, Leila

AU - West, Catharine M L

AU - Burnet, Neil G

AU - Elliott, Rebecca

AU - Coles, Charlotte

AU - Hall, Emma

AU - Fachal, Laura

AU - Vega, Ana

AU - Gómez-Caamaño, Antonio

AU - Talbot, Christopher J

AU - Symonds, R Paul

AU - De Ruyck, Kim

AU - Thierens, Hubert

AU - Ost, Piet

AU - Chang-Claude, Jenny

AU - Seibold, Petra

AU - Popanda, Odilia

AU - Overgaard, Marie

AU - Dearnaley, David

AU - Sydes, Matthew R

AU - Azria, David

AU - Koch, Christine Anne

AU - Parliament, Matthew

AU - Blackshaw, Michael

AU - Sia, Michael

AU - Fuentes-Raspall, Maria J

AU - Ramon Y Cajal, Teresa

AU - Barnadas, Agustin

AU - Vesprini, Danny

AU - Gutiérrez-Enríquez, Sara

AU - Mollà, Meritxell

AU - Díez, Orland

AU - Yarnold, John R

AU - Overgaard, Jens

AU - Bentzen, Søren M

AU - Alsner, Jan

AU - International Radiogenomics Consortium (RgC)

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/12

Y1 - 2016/12

N2 - PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

AB - PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

KW - Alleles

KW - Ataxia Telangiectasia Mutated Proteins

KW - Breast Neoplasms

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

KW - Radiation Injuries

KW - Radiation Tolerance

KW - Radiotherapy

KW - Risk Factors

KW - Journal Article

KW - Meta-Analysis

KW - Research Support, Non-U.S. Gov't

KW - Research Support, N.I.H., Extramural

U2 - 10.1016/j.radonc.2016.06.017

DO - 10.1016/j.radonc.2016.06.017

M3 - Article

VL - 121

SP - 431

EP - 439

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

IS - 3

ER -