Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control studyCitation formats

  • Authors:
  • Sarah Scrivener
  • Haile Yemaneberhan
  • Mehila Zebenigus
  • Daniel Tilahun
  • Samuel Girma
  • And 7 others
  • External authors:
  • Seid Ali
  • Paul McElroy
  • Adnan Custovic
  • Ashley Woodcock
  • David Pritchard
  • Andrea Venn
  • John Britton

Standard

Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study. / Scrivener, Sarah; Yemaneberhan, Haile; Zebenigus, Mehila; Tilahun, Daniel; Girma, Samuel; Ali, Seid; McElroy, Paul; Custovic, Adnan; Woodcock, Ashley; Pritchard, David; Venn, Andrea; Britton, John.

In: The Lancet, Vol. 358, No. 9292, 03.11.2001, p. 1493-1499.

Research output: Contribution to journalArticle

Harvard

Scrivener, S, Yemaneberhan, H, Zebenigus, M, Tilahun, D, Girma, S, Ali, S, McElroy, P, Custovic, A, Woodcock, A, Pritchard, D, Venn, A & Britton, J 2001, 'Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study' The Lancet, vol. 358, no. 9292, pp. 1493-1499. https://doi.org/10.1016/S0140-6736(01)06579-5

APA

Scrivener, S., Yemaneberhan, H., Zebenigus, M., Tilahun, D., Girma, S., Ali, S., ... Britton, J. (2001). Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study. The Lancet, 358(9292), 1493-1499. https://doi.org/10.1016/S0140-6736(01)06579-5

Vancouver

Author

Scrivener, Sarah ; Yemaneberhan, Haile ; Zebenigus, Mehila ; Tilahun, Daniel ; Girma, Samuel ; Ali, Seid ; McElroy, Paul ; Custovic, Adnan ; Woodcock, Ashley ; Pritchard, David ; Venn, Andrea ; Britton, John. / Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study. In: The Lancet. 2001 ; Vol. 358, No. 9292. pp. 1493-1499.

Bibtex

@article{f9e44c0d870a4187bb66d0ee54cf1738,
title = "Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study",
abstract = "Background: Why asthma is rare in rural subsistence societies is not clear. We tested the hypotheses that the risk of asthma is reduced by intestinal parasites or hepatitis A infection, and increased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas of Jimma, Ethiopia. Methods: From 12 876 individuals who took part in a study of asthma and atopy in urban and rural Jimma in 1996, we identified all who reported wheeze in the previous 12 months, and a random subsample of controls. In 1999, we assessed parasites in faecal samples, Der p 1 levels in bedding, hepatitis A antibodies, serum cholinesterase (a marker of organophosphorus exposure), total and specific serum IgE, and skin sensitisation to Dermatophagoides pteronyssinus in 205 cases and 399 controls aged over 16 years. The effects of parasitosis, Der p 1 level, hepatitis A seropositivity, and cholinesterase concentration on risk of wheeze, and the role of IgE and skin sensitisation in these associations, were analysed by multiple logistic regression. Findings: The risk of wheeze was independently reduced by hookworm infection by an odds ratio of 0.48 (95{\%} CI 0.24-0.93, p=0.03), increased in relation to Der p 1 level (odds ratio per quartile 1.26 [1.00-1.59], p=0.05), and was unrelated to hepatitis A seropositivity or cholinesterase concentration. In the urban population, D pteronyssinus skin sensitisation was more strongly related to wheeze (9.45 [5.03-17.75]) than in the rural areas (1.95 [0.58-6.61], p for interaction=0.017), where D pteronyssinus sensitisation was common, but unrelated to wheeze in the presence of high-intensity parasite infection. Interpretation: High degrees of parasite infection might prevent asthma symptoms in atopic individuals.",
keywords = "Adolescent, Adult, Antigens, Dermatophagoides, epidemiology: Asthma, Case-Control Studies, Comparative Study, Cross-Sectional Studies, epidemiology: Ethiopia, parasitology: Feces, Female, immunology: Glycoproteins, Humans, parasitology: Intestinal Diseases, Logistic Models, Male, Middle Aged, Research Support, Non-U.S. Gov't, Respiratory Sounds, Risk Factors, Rural Population, Urban Population",
author = "Sarah Scrivener and Haile Yemaneberhan and Mehila Zebenigus and Daniel Tilahun and Samuel Girma and Seid Ali and Paul McElroy and Adnan Custovic and Ashley Woodcock and David Pritchard and Andrea Venn and John Britton",
year = "2001",
month = "11",
day = "3",
doi = "10.1016/S0140-6736(01)06579-5",
language = "English",
volume = "358",
pages = "1493--1499",
journal = "The Lancet",
issn = "0140-6736",
publisher = "The Lancet Publishing Group",
number = "9292",

}

RIS

TY - JOUR

T1 - Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: A nested case-control study

AU - Scrivener, Sarah

AU - Yemaneberhan, Haile

AU - Zebenigus, Mehila

AU - Tilahun, Daniel

AU - Girma, Samuel

AU - Ali, Seid

AU - McElroy, Paul

AU - Custovic, Adnan

AU - Woodcock, Ashley

AU - Pritchard, David

AU - Venn, Andrea

AU - Britton, John

PY - 2001/11/3

Y1 - 2001/11/3

N2 - Background: Why asthma is rare in rural subsistence societies is not clear. We tested the hypotheses that the risk of asthma is reduced by intestinal parasites or hepatitis A infection, and increased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas of Jimma, Ethiopia. Methods: From 12 876 individuals who took part in a study of asthma and atopy in urban and rural Jimma in 1996, we identified all who reported wheeze in the previous 12 months, and a random subsample of controls. In 1999, we assessed parasites in faecal samples, Der p 1 levels in bedding, hepatitis A antibodies, serum cholinesterase (a marker of organophosphorus exposure), total and specific serum IgE, and skin sensitisation to Dermatophagoides pteronyssinus in 205 cases and 399 controls aged over 16 years. The effects of parasitosis, Der p 1 level, hepatitis A seropositivity, and cholinesterase concentration on risk of wheeze, and the role of IgE and skin sensitisation in these associations, were analysed by multiple logistic regression. Findings: The risk of wheeze was independently reduced by hookworm infection by an odds ratio of 0.48 (95% CI 0.24-0.93, p=0.03), increased in relation to Der p 1 level (odds ratio per quartile 1.26 [1.00-1.59], p=0.05), and was unrelated to hepatitis A seropositivity or cholinesterase concentration. In the urban population, D pteronyssinus skin sensitisation was more strongly related to wheeze (9.45 [5.03-17.75]) than in the rural areas (1.95 [0.58-6.61], p for interaction=0.017), where D pteronyssinus sensitisation was common, but unrelated to wheeze in the presence of high-intensity parasite infection. Interpretation: High degrees of parasite infection might prevent asthma symptoms in atopic individuals.

AB - Background: Why asthma is rare in rural subsistence societies is not clear. We tested the hypotheses that the risk of asthma is reduced by intestinal parasites or hepatitis A infection, and increased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas of Jimma, Ethiopia. Methods: From 12 876 individuals who took part in a study of asthma and atopy in urban and rural Jimma in 1996, we identified all who reported wheeze in the previous 12 months, and a random subsample of controls. In 1999, we assessed parasites in faecal samples, Der p 1 levels in bedding, hepatitis A antibodies, serum cholinesterase (a marker of organophosphorus exposure), total and specific serum IgE, and skin sensitisation to Dermatophagoides pteronyssinus in 205 cases and 399 controls aged over 16 years. The effects of parasitosis, Der p 1 level, hepatitis A seropositivity, and cholinesterase concentration on risk of wheeze, and the role of IgE and skin sensitisation in these associations, were analysed by multiple logistic regression. Findings: The risk of wheeze was independently reduced by hookworm infection by an odds ratio of 0.48 (95% CI 0.24-0.93, p=0.03), increased in relation to Der p 1 level (odds ratio per quartile 1.26 [1.00-1.59], p=0.05), and was unrelated to hepatitis A seropositivity or cholinesterase concentration. In the urban population, D pteronyssinus skin sensitisation was more strongly related to wheeze (9.45 [5.03-17.75]) than in the rural areas (1.95 [0.58-6.61], p for interaction=0.017), where D pteronyssinus sensitisation was common, but unrelated to wheeze in the presence of high-intensity parasite infection. Interpretation: High degrees of parasite infection might prevent asthma symptoms in atopic individuals.

KW - Adolescent

KW - Adult

KW - Antigens, Dermatophagoides

KW - epidemiology: Asthma

KW - Case-Control Studies

KW - Comparative Study

KW - Cross-Sectional Studies

KW - epidemiology: Ethiopia

KW - parasitology: Feces

KW - Female

KW - immunology: Glycoproteins

KW - Humans

KW - parasitology: Intestinal Diseases

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Research Support, Non-U.S. Gov't

KW - Respiratory Sounds

KW - Risk Factors

KW - Rural Population

KW - Urban Population

U2 - 10.1016/S0140-6736(01)06579-5

DO - 10.1016/S0140-6736(01)06579-5

M3 - Article

VL - 358

SP - 1493

EP - 1499

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9292

ER -