Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.Citation formats

  • External authors:
  • E Griffiths
  • S Pritchard
  • S McGrath
  • HR Valentine
  • PM Price
  • I Welch

Standard

Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. / West, CML.; Griffiths, E; Pritchard, S; McGrath, S; Valentine, HR; Price, PM; Welch, I.

In: Br J Cancer, Vol. 96( 9), 07.05.2007.

Research output: Contribution to journalArticlepeer-review

Harvard

West, CML, Griffiths, E, Pritchard, S, McGrath, S, Valentine, HR, Price, PM & Welch, I 2007, 'Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.', Br J Cancer, vol. 96( 9).

APA

West, CML., Griffiths, E., Pritchard, S., McGrath, S., Valentine, HR., Price, PM., & Welch, I. (2007). Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Br J Cancer, 96( 9).

Vancouver

West CML, Griffiths E, Pritchard S, McGrath S, Valentine HR, Price PM et al. Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Br J Cancer. 2007 May 7;96( 9).

Author

West, CML. ; Griffiths, E ; Pritchard, S ; McGrath, S ; Valentine, HR ; Price, PM ; Welch, I. / Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. In: Br J Cancer. 2007 ; Vol. 96( 9).

Bibtex

@article{535105e5a5894f4b8789e3c02156826a,
title = "Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.",
abstract = "Hypoxia-associated markers are involved in the progression of several malignancies, but are relatively unstudied in Barrett's carcinogenesis. Our aim was to assess the immunohistochemical expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, erythropoietin (Epo), Epo receptor (Epo-R), Glut-1 and vascular endothelial growth factor (VEGF) along with Ki67/MIB-1 in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Endoscopic biopsies of normal squamous epithelium (NSE) (n=20), columnar-lined oesophagus (CLO) (n=15), CLO with intestinal metaplasia (n=20), dysplasia (n=17) and Barrett's type adenocarcinoma (n=20) were obtained. Immunohistochemistry was performed on the paraffin-embedded tissue. A score was calculated for each marker (range 0-300) by multiplying intensity (none 0, weak 1, moderate 2, strong 3) by percentage of expression (range 0-100). Significant increases in the expression of HIF-2alpha (P=0.014), VEGF (P",
author = "CML. West and E Griffiths and S Pritchard and S McGrath and HR Valentine and PM Price and I Welch",
year = "2007",
month = may,
day = "7",
language = "English",
volume = "96( 9)",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence.

AU - West, CML.

AU - Griffiths, E

AU - Pritchard, S

AU - McGrath, S

AU - Valentine, HR

AU - Price, PM

AU - Welch, I

PY - 2007/5/7

Y1 - 2007/5/7

N2 - Hypoxia-associated markers are involved in the progression of several malignancies, but are relatively unstudied in Barrett's carcinogenesis. Our aim was to assess the immunohistochemical expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, erythropoietin (Epo), Epo receptor (Epo-R), Glut-1 and vascular endothelial growth factor (VEGF) along with Ki67/MIB-1 in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Endoscopic biopsies of normal squamous epithelium (NSE) (n=20), columnar-lined oesophagus (CLO) (n=15), CLO with intestinal metaplasia (n=20), dysplasia (n=17) and Barrett's type adenocarcinoma (n=20) were obtained. Immunohistochemistry was performed on the paraffin-embedded tissue. A score was calculated for each marker (range 0-300) by multiplying intensity (none 0, weak 1, moderate 2, strong 3) by percentage of expression (range 0-100). Significant increases in the expression of HIF-2alpha (P=0.014), VEGF (P

AB - Hypoxia-associated markers are involved in the progression of several malignancies, but are relatively unstudied in Barrett's carcinogenesis. Our aim was to assess the immunohistochemical expression of hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, erythropoietin (Epo), Epo receptor (Epo-R), Glut-1 and vascular endothelial growth factor (VEGF) along with Ki67/MIB-1 in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Endoscopic biopsies of normal squamous epithelium (NSE) (n=20), columnar-lined oesophagus (CLO) (n=15), CLO with intestinal metaplasia (n=20), dysplasia (n=17) and Barrett's type adenocarcinoma (n=20) were obtained. Immunohistochemistry was performed on the paraffin-embedded tissue. A score was calculated for each marker (range 0-300) by multiplying intensity (none 0, weak 1, moderate 2, strong 3) by percentage of expression (range 0-100). Significant increases in the expression of HIF-2alpha (P=0.014), VEGF (P

M3 - Article

VL - 96( 9)

JO - BJC

JF - BJC

SN - 0007-0920

ER -