BACKGROUND: The burden of psoriasis across many world regions is high and there is a recognised need to better understand the epidemiology of this common skin disorder.
OBJECTIVES: To examine changes in the prevalence and incidence of psoriasis, and mortality rates over a 15 year period.
METHODS: Cohort study involving analysis of longitudinal electronic health records between 1999 and 2013 using the UK Clinical Practice Research Datalink (CPRD).
RESULTS: The prevalence of psoriasis increased steadily from 2.3% (2297 cases per 100,000) in 1999 to 2.8% (2815 per 100,000) in 2013, which does not appear to be attributable to changes in incidence rates. We observed peaks in age-bands characteristic of early (type I) and late-onset (type II) psoriasis, and changes in incidence and prevalence rates with increasing latitude in the UK. All-cause mortality rates for the general population and for patients with psoriasis have decreased over the last 15 years. However, the risk of all-cause mortality for psoriasis patients remains elevated compared to people without psoriasis (hazard ratio (HR) 1.21; 95% CI 1.13-1.3) and we found no significant change in this relative excess mortality gap over time.
CONCLUSIONS: We found an increasing population living longer with psoriasis in the UK which has important implications for healthcare service delivery and for resource allocation. Importantly, early mortality in patients with psoriasis remains elevated compared to the general population and we found no evidence of change in this premature mortality gap. This article is protected by copyright. All rights reserved.