Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

Research output: Contribution to journalArticle

  • External authors:
  • Rahul Yadav
  • Michael France
  • Reza Aghamohammadzadeh
  • Yifen Liu
  • Salam Hama
  • Jonathan Schofield
  • Peter Turkington
  • Rayaz Malik
  • Philip Pemberton
  • Paul Durrington
  • Basil Ammori
  • Martin Gibson
  • Handrean Soran

Abstract

© 2014 by the Endocrine Society.Design and Patients: Morbidly obese patients (n = 41) were divided into those whose apneahypoapnea index (AHI) was more or less than the median value and on the presence of OSA [OSA and no OSA (nOSA) groups]. We studied the antioxidant function of HDL and measured serum paraoxonase 1 (PON1) activity, TNFα, and intercellular adhesion molecule 1 (ICAM-1) levels in these patients. In a subset of 19 patients, we immunostained gluteal sc adipose tissue (SAT) for TNFα, macrophages, and measured adipocyte size.Results: HDL lipid peroxide levels were higher and serum PON1 activity was lower in the high AHI group vs the low AHI group (P

Bibliographical metadata

Original languageEnglish
Pages (from-to)3390-3398
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number9
DOIs
Publication statusPublished - 1 Sep 2014