Impact of biologic therapies on quality of life of psoriasis patients: results from the British Association of Dermatologists Biologic Interventions Register
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Abstract
The quality of life (QoL) of psoriasis patients receiving biologic therapies in the "real-world" is relatively unknown. We assessed the impact of biologics on QoL & studied potential predictors for improved QoL, using a cohort of 2152 psoriasis patients (adalimumab (n=1239), etanercept (n=517) & ustekinumab (n=396); 81% were biologic-naïve) registered with the British Association of Dermatologists Biologic Interventions Register & followed-up for ≥6-months. Changes in QoL were assessed using the Dermatology Life Quality Index (DLQI) & EuroQoL-5D (EQ5D) at 6 & 12-months. For the entire cohort, the median (interquartile range) DLQI & EQ5D utility score improved from 18(13-24) & 0.7(0.6-0.8) at baseline to 2(0-7) & 0.9(0.7-1.0) at 6-months (p<0.0001), respectively; 46% & 54% of patients achieved a DLQI of 0/1 & a clinically meaningful change of ≥0.05 in their EQ5D. Improvements were generally maintained at 12-months. At 6-months the multivariable regression models showed that patients who were obese, with multiple comorbidities, & with lower QoL at baseline were significantly less likely to show either EQ5D improvements or achieve a DLQI of 0/1. As compared with adalimumab, patients on etanercept were less likely to achieve a DLQI of 0/1, however, there was no significant difference between the three biologics in improvement in EQ5D. Age, smoking & psoriatic arthritis were determinants of poor improvement in EQ5D. Similar factors were associated with QoL improvement at 12-months. In routine clinical practice, biologics were associated with improvement in QoL in psoriasis patients. The results of this study will help to inform clinical decisions in psoriasis management.
Bibliographical metadata
Original language | English |
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Title of host publication | Journal of Investigative Dermatology |
Pages | S161-S294 |
Volume | 136 |
Edition | Issue 9, Supplement 2 |
DOIs | |
Publication status | Published - Sep 2016 |
Event | European Society for Dermatological Research - Technical University of Munich (TUM), Department of Mechanical Engineering, Munich, Germany Event duration: 7 Sep 2016 → 10 Sep 2016 Conference number: 46th |
Conference
Conference | European Society for Dermatological Research |
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Abbreviated title | ESDR |
Country | Germany |
City | Munich |
Period | 7/09/16 → 10/09/16 |