Imine reductases (IREDs)

Research output: Contribution to journalReview article

  • External authors:
  • Juan Mangas-Sanchez
  • Scott P. France
  • Sarah L. Montgomery
  • Godwin A. Aleku
  • Henry Man
  • Mahima Sharma
  • Jeremy I. Ramsden
  • Gideon Grogan

Abstract

Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.

Bibliographical metadata

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume37
DOIs
Publication statusPublished - 1 Apr 2017