Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate CancerCitation formats

  • Authors:
  • Lucy Kershaw
  • Laila van Zadelhoff
  • Wilma Heemsbergen
  • Floris Pos
  • Marcel van Herk

Standard

Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer : Motion and Margins. / Kershaw, Lucy; van Zadelhoff, Laila; Heemsbergen, Wilma; Pos, Floris; van Herk, Marcel.

In: International Journal of Radiation Oncology Biology Physics, 01.01.2018.

Research output: Contribution to journalArticle

Harvard

Kershaw, L, van Zadelhoff, L, Heemsbergen, W, Pos, F & van Herk, M 2018, 'Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer: Motion and Margins' International Journal of Radiation Oncology Biology Physics. https://doi.org/10.1016/j.ijrobp.2017.08.044

APA

Kershaw, L., van Zadelhoff, L., Heemsbergen, W., Pos, F., & van Herk, M. (2018). Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer: Motion and Margins. International Journal of Radiation Oncology Biology Physics. https://doi.org/10.1016/j.ijrobp.2017.08.044

Vancouver

Kershaw L, van Zadelhoff L, Heemsbergen W, Pos F, van Herk M. Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer: Motion and Margins. International Journal of Radiation Oncology Biology Physics. 2018 Jan 1. https://doi.org/10.1016/j.ijrobp.2017.08.044

Author

Kershaw, Lucy ; van Zadelhoff, Laila ; Heemsbergen, Wilma ; Pos, Floris ; van Herk, Marcel. / Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer : Motion and Margins. In: International Journal of Radiation Oncology Biology Physics. 2018.

Bibtex

@article{fc65a6c9fc34408ca55c61a3c2ec1845,
title = "Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer: Motion and Margins",
abstract = "Purpose: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. Methods and Materials: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan. Systematic and random uncertainties were determined along with correlations between the motions of these regions. The clinical target volume to planning target volume margins required to take only motion into account were calculated for each guidance method. Results: For bone guidance, motion of the prostate and LNs was largely uncorrelated. Margins to compensate for motion (left-right, superior-inferior, anterior-posterior, in cm) based on a 3-DOF couch were as follows: prostate (0.2, 0.6, 0.8), SV (0.4, 0.9, 1.0), and LNs (0.3, 0.4, 0.6). For prostate guidance, margins were calculated for correlated motion: prostate (0, 0, 0), SV (0.3, 0.5, 0.4), and LNs (0.3, 0.5, 0.9). For a 6-DOF couch, these margins were as follows: prostate (0.2, 0.6, 0.8), SV (0.3, 0.9, 1.0), and LNs (0.3, 0.4, 0.3) for bone guidance. For prostate guidance, margins were as follows: prostate (0, 0, 0), SV (0.2, 0.5, 0.4), and LNs (0.3, 0.6, 0.6). Conclusions: Image guided radiation therapy based on bony anatomy requires larger prostate and SV margins, and guidance on prostate requires larger LN margins. Neither guidance strategy is optimal, and a combination of the 2 or treatment adaptation after a number of fractions might be preferable. Calculation of the total margin should also include delineation uncertainties.",
author = "Lucy Kershaw and {van Zadelhoff}, Laila and Wilma Heemsbergen and Floris Pos and {van Herk}, Marcel",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.ijrobp.2017.08.044",
language = "English",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Image Guided Radiation Therapy Strategies for Pelvic Lymph Node Irradiation in High-Risk Prostate Cancer

T2 - Motion and Margins

AU - Kershaw, Lucy

AU - van Zadelhoff, Laila

AU - Heemsbergen, Wilma

AU - Pos, Floris

AU - van Herk, Marcel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. Methods and Materials: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan. Systematic and random uncertainties were determined along with correlations between the motions of these regions. The clinical target volume to planning target volume margins required to take only motion into account were calculated for each guidance method. Results: For bone guidance, motion of the prostate and LNs was largely uncorrelated. Margins to compensate for motion (left-right, superior-inferior, anterior-posterior, in cm) based on a 3-DOF couch were as follows: prostate (0.2, 0.6, 0.8), SV (0.4, 0.9, 1.0), and LNs (0.3, 0.4, 0.6). For prostate guidance, margins were calculated for correlated motion: prostate (0, 0, 0), SV (0.3, 0.5, 0.4), and LNs (0.3, 0.5, 0.9). For a 6-DOF couch, these margins were as follows: prostate (0.2, 0.6, 0.8), SV (0.3, 0.9, 1.0), and LNs (0.3, 0.4, 0.3) for bone guidance. For prostate guidance, margins were as follows: prostate (0, 0, 0), SV (0.2, 0.5, 0.4), and LNs (0.3, 0.6, 0.6). Conclusions: Image guided radiation therapy based on bony anatomy requires larger prostate and SV margins, and guidance on prostate requires larger LN margins. Neither guidance strategy is optimal, and a combination of the 2 or treatment adaptation after a number of fractions might be preferable. Calculation of the total margin should also include delineation uncertainties.

AB - Purpose: To quantify the relative motion of the pelvic lymph nodes (LNs), seminal vesicles (SV) and prostate and define indicative margins for image-guided radiotherapy based on bony anatomy or prostate correction strategies for a 3 or 6 degrees-of-freedom couch. Methods and Materials: Nineteen patients had a planning computed tomography (CT) scan followed by a mean of 11 repeated CT scans during radiation therapy. The prostate, SV, and external and internal iliac LN regions on the left and right were outlined on each CT scan. Systematic and random uncertainties were determined along with correlations between the motions of these regions. The clinical target volume to planning target volume margins required to take only motion into account were calculated for each guidance method. Results: For bone guidance, motion of the prostate and LNs was largely uncorrelated. Margins to compensate for motion (left-right, superior-inferior, anterior-posterior, in cm) based on a 3-DOF couch were as follows: prostate (0.2, 0.6, 0.8), SV (0.4, 0.9, 1.0), and LNs (0.3, 0.4, 0.6). For prostate guidance, margins were calculated for correlated motion: prostate (0, 0, 0), SV (0.3, 0.5, 0.4), and LNs (0.3, 0.5, 0.9). For a 6-DOF couch, these margins were as follows: prostate (0.2, 0.6, 0.8), SV (0.3, 0.9, 1.0), and LNs (0.3, 0.4, 0.3) for bone guidance. For prostate guidance, margins were as follows: prostate (0, 0, 0), SV (0.2, 0.5, 0.4), and LNs (0.3, 0.6, 0.6). Conclusions: Image guided radiation therapy based on bony anatomy requires larger prostate and SV margins, and guidance on prostate requires larger LN margins. Neither guidance strategy is optimal, and a combination of the 2 or treatment adaptation after a number of fractions might be preferable. Calculation of the total margin should also include delineation uncertainties.

UR - http://www.scopus.com/inward/record.url?scp=85031666042&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2017.08.044

DO - 10.1016/j.ijrobp.2017.08.044

M3 - Article

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

ER -