Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosisCitation formats

  • External authors:
  • E. A. Griffiths
  • S. A. Pritchard
  • S. M. McGrath
  • H. R. Valentine
  • P. M. Price
  • I. M. Welch
  • C. M L West

Standard

Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. / West, Catharine; Griffiths, E. A.; Pritchard, S. A.; McGrath, S. M.; Valentine, H. R.; Price, P. M.; Welch, I. M.; West, C. M L.

In: British Journal of Cancer, Vol. 98, No. 5, 11.03.2008, p. 965-973.

Research output: Contribution to journalArticlepeer-review

Harvard

West, C, Griffiths, EA, Pritchard, SA, McGrath, SM, Valentine, HR, Price, PM, Welch, IM & West, CML 2008, 'Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis', British Journal of Cancer, vol. 98, no. 5, pp. 965-973. https://doi.org/10.1038/sj.bjc.6604210

APA

West, C., Griffiths, E. A., Pritchard, S. A., McGrath, S. M., Valentine, H. R., Price, P. M., Welch, I. M., & West, C. M. L. (2008). Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. British Journal of Cancer, 98(5), 965-973. https://doi.org/10.1038/sj.bjc.6604210

Vancouver

West C, Griffiths EA, Pritchard SA, McGrath SM, Valentine HR, Price PM et al. Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. British Journal of Cancer. 2008 Mar 11;98(5):965-973. https://doi.org/10.1038/sj.bjc.6604210

Author

West, Catharine ; Griffiths, E. A. ; Pritchard, S. A. ; McGrath, S. M. ; Valentine, H. R. ; Price, P. M. ; Welch, I. M. ; West, C. M L. / Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. In: British Journal of Cancer. 2008 ; Vol. 98, No. 5. pp. 965-973.

Bibtex

@article{5dda7480f67540408cff0f0202ba0b9f,
title = "Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis",
abstract = "The study investigated hypoxia-associated markers (HIF-2α, Epo, Epo-R, Glut-1 and VEGF) along with Ki-67 in a gastric carcinogenesis model, and the prognostic significance of hypoxia-inducible factor (HIF)-2α in surgically treated gastro-oesophageal cancer. Protein expression was examined using immunohistochemistry on formalin-fixed, paraffin-embedded biopsies of normal mucosa (n=20), Helicobacter pylori-associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. Relationships between HIF-2α expression and prognosis were assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Expression of all markers increased with progression along the gastric carcinogenesis sequence (P=0.0001). Hypoxia-inducible factor-2α was expressed in 63% of 177 resection specimens and at a high level in 44%. The median overall survival in patients with HIF-2α-expressing tumours was 22 (95% CI 18-26) months, whereas those with HIF-2α-negative tumours had a median survival of 37 (95% CI 29-44) months (P=0.015). Hypoxia-inducible factor-2α had no independent prognostic significance in multivariate analysis. In view of the lack of independent prognostic significance, HIF-2α has no role as a routine prognostic indicator. However, the high expression of HIF-2α suggests that it may be of value as a potential therapeutic target. {\textcopyright} 2008 Cancer Research UK.",
keywords = "Carcinogenesis, Gastric cancer, Gastro-oesophageal junction tumours, HIF-2α, Hypoxia",
author = "Catharine West and Griffiths, {E. A.} and Pritchard, {S. A.} and McGrath, {S. M.} and Valentine, {H. R.} and Price, {P. M.} and Welch, {I. M.} and West, {C. M L}",
year = "2008",
month = mar,
day = "11",
doi = "10.1038/sj.bjc.6604210",
language = "English",
volume = "98",
pages = "965--973",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis

AU - West, Catharine

AU - Griffiths, E. A.

AU - Pritchard, S. A.

AU - McGrath, S. M.

AU - Valentine, H. R.

AU - Price, P. M.

AU - Welch, I. M.

AU - West, C. M L

PY - 2008/3/11

Y1 - 2008/3/11

N2 - The study investigated hypoxia-associated markers (HIF-2α, Epo, Epo-R, Glut-1 and VEGF) along with Ki-67 in a gastric carcinogenesis model, and the prognostic significance of hypoxia-inducible factor (HIF)-2α in surgically treated gastro-oesophageal cancer. Protein expression was examined using immunohistochemistry on formalin-fixed, paraffin-embedded biopsies of normal mucosa (n=20), Helicobacter pylori-associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. Relationships between HIF-2α expression and prognosis were assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Expression of all markers increased with progression along the gastric carcinogenesis sequence (P=0.0001). Hypoxia-inducible factor-2α was expressed in 63% of 177 resection specimens and at a high level in 44%. The median overall survival in patients with HIF-2α-expressing tumours was 22 (95% CI 18-26) months, whereas those with HIF-2α-negative tumours had a median survival of 37 (95% CI 29-44) months (P=0.015). Hypoxia-inducible factor-2α had no independent prognostic significance in multivariate analysis. In view of the lack of independent prognostic significance, HIF-2α has no role as a routine prognostic indicator. However, the high expression of HIF-2α suggests that it may be of value as a potential therapeutic target. © 2008 Cancer Research UK.

AB - The study investigated hypoxia-associated markers (HIF-2α, Epo, Epo-R, Glut-1 and VEGF) along with Ki-67 in a gastric carcinogenesis model, and the prognostic significance of hypoxia-inducible factor (HIF)-2α in surgically treated gastro-oesophageal cancer. Protein expression was examined using immunohistochemistry on formalin-fixed, paraffin-embedded biopsies of normal mucosa (n=20), Helicobacter pylori-associated gastritis (n=24), intestinal metaplasia (n=24), dysplasia (n=12) and intestinal (n=19) and diffuse (n=21) adenocarcinoma. Relationships between HIF-2α expression and prognosis were assessed in resection specimens from 177 patients with gastric and gastro-oesophageal junction adenocarcinoma. Expression of all markers increased with progression along the gastric carcinogenesis sequence (P=0.0001). Hypoxia-inducible factor-2α was expressed in 63% of 177 resection specimens and at a high level in 44%. The median overall survival in patients with HIF-2α-expressing tumours was 22 (95% CI 18-26) months, whereas those with HIF-2α-negative tumours had a median survival of 37 (95% CI 29-44) months (P=0.015). Hypoxia-inducible factor-2α had no independent prognostic significance in multivariate analysis. In view of the lack of independent prognostic significance, HIF-2α has no role as a routine prognostic indicator. However, the high expression of HIF-2α suggests that it may be of value as a potential therapeutic target. © 2008 Cancer Research UK.

KW - Carcinogenesis

KW - Gastric cancer

KW - Gastro-oesophageal junction tumours

KW - HIF-2α

KW - Hypoxia

U2 - 10.1038/sj.bjc.6604210

DO - 10.1038/sj.bjc.6604210

M3 - Article

VL - 98

SP - 965

EP - 973

JO - BJC

JF - BJC

SN - 0007-0920

IS - 5

ER -