Hypoxia in head and neck cancerCitation formats
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Hypoxia in head and neck cancer. / Isa, A. Y.; Ward, T. H.; West, C. M L; Slevin, N. J.; Homer, J. J.
In: British Journal of Radiology, Vol. 79, No. 946, 10.2006, p. 791-798.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Hypoxia in head and neck cancer
AU - Isa, A. Y.
AU - Ward, T. H.
AU - West, C. M L
AU - Slevin, N. J.
AU - Homer, J. J.
PY - 2006/10
Y1 - 2006/10
N2 - A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. © 2006 The British Institute of Radiology.
AB - A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies. © 2006 The British Institute of Radiology.
KW - therapeutic use: Antibiotics, Antineoplastic
KW - analysis: Basic Helix-Loop-Helix Transcription Factors
KW - analysis: Biological Markers
KW - Cell Hypoxia
KW - Comet Assay
KW - blood supply: Head and Neck Neoplasms
KW - metabolism: Hemoglobins
KW - Humans
KW - analysis: Hypoxia-Inducible Factor 1, alpha Subunit
KW - Microelectrodes
KW - diagnostic use: Nitroimidazoles
KW - administration & dosage: Oxygen
KW - methods: Positron-Emission Tomography
KW - Prognosis
KW - therapeutic use: Radiation-Sensitizing Agents
U2 - 10.1259/bjr/17904358
DO - 10.1259/bjr/17904358
M3 - Article
VL - 79
SP - 791
EP - 798
JO - British Journal of Radiology
JF - British Journal of Radiology
SN - 0007-1285
IS - 946
ER -