How not to get scar(r)ed: Pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • M. J. Harries
  • R. M. Trueb
  • A. Tosti
  • A. G. Messenger
  • I. Chaudhry
  • D. A. Whiting
  • R. Sinclair


Primary cicatricial alopecias (PCAs) are a rare, but important, group of disorders that cause irreversible damage to hair follicles resulting in scarring and permanent hair loss. They may also signify an underlying systemic disease. Thus, it is of paramount importance that clinicians who manage patients with hair loss are able to diagnose these disorders accurately. Unfortunately, PCAs are notoriously difficult conditions to diagnose and treat. The aim of this review is to present a rational and pragmatic guide to help clinicians in the professional assessment, investigation and diagnosis of patients with PCA. Illustrating typical clinical and histopathological presentations of key PCA entities we show how dermatoscopy can be profitably used for clinical diagnosis. Further, we advocate the search for loss of follicular ostia as a clinical hallmark of PCA, and suggest pragmatic strategies that allow rapid formulation of a working diagnosis. © 2009 The Authors.

Bibliographical metadata

Original languageEnglish
Pages (from-to)482-501
Number of pages19
JournalBritish Journal of Dermatology
Issue number3
Publication statusPublished - Mar 2009