How LC-MS Proteomics is Revolutionizing PBPK Modelling and Simulation

Research output: Contribution to conferenceOther

Abstract

Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition and therefore have major implications on the fate of drugs in the human body. Recently, an increasing number of studies have reported proteomic expression data for pharmacologically relevant enzymes and transporters providing rich data that can be used for simulation and modelling. However, systematic analysis and understanding of the expression of these proteins in human tissue and commonly used in vitro systems is lacking. New LC-MS techniques in quantitative proteomics are transforming the approach to quantitative pharmacology and in vitro-in vivo extrapolation (IVIVE) for physiologically-based pharmacokinetic (PBPK) models. In this webinar, Dr. Amin Rostami (Certara) and Dr. Brahim Achour (University of Manchester) will discuss the scientific and economic implications of this approach on the IVIVE of enzyme and transporter-mediated drug pharmacokinetics using PBPK models.

Bibliographical metadata

Original languageEnglish
Publication statusPublished - 18 Feb 2015
EventCertara 2015 Scientific Webinar Series - Simcyp Ltd., Sheffield
Event duration: 18 Feb 2015 → …

Conference

ConferenceCertara 2015 Scientific Webinar Series
CitySimcyp Ltd., Sheffield
Period18/02/15 → …