Homeodomain proteins in action: similar DNA binding preferences, highly variable connectivity.

Research output: Contribution to journalArticle


Abstract: Homeodomain proteins are evolutionary conserved proteins
present in the entire eukaryote kingdom. They execute functions that are
essential for life, both in developing and adult organisms. Most
homeodomain proteins act as transcription factors and bind DNA to control
the activity of other genes. In contrast to their similar DNA binding
specificity, homeodomain proteins execute highly diverse and contextdependent
functions. Several factors, including genome accessibility, DNA
shape, combinatorial binding and the ability to interact with many
transcriptional partners, diversify the activity of homeodomain proteins
and culminate in the activation of highly dynamic, context-specific
transcriptional programs. Clarifying how homeodomain transcription
factors work is central to our understanding of development, disease and

Bibliographical metadata

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCurrent Opinion in Genetics and Development
Early online date19 Oct 2016
StatePublished - Apr 2017