Herpes Viruses and Senile Dementia: First Population Evidence for a Causal LinkCitation formats

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Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link. / Itzhaki, Ruth; Lathe, R.

In: Journal of Alzheimer's Disease, Vol. 64, No. 2, 19.06.2018.

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Itzhaki, Ruth ; Lathe, R. / Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link. In: Journal of Alzheimer's Disease. 2018 ; Vol. 64, No. 2.

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@article{f0aaa133a3f6470f9f49687b9985ad69,
title = "Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link",
abstract = "Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potentialtreatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al., published in the January/February2018 issue of Journal of Clinical Psychiatry) demonstrate an increased risk of subsequent senile dementia (SD) developmentin patients with acute varicella zoster (herpes zoster) infection. These articles present data highly relevant to the third, andmost important, paper—by Tzeng et al., published online in the journal Neurotherapeutics at the end of February 2018.These authors report that infection with a different herpes virus, herpes simplex virus type 1 (HSV1), leads to a similarlyincreased risk of later developing SD. Further, when the authors looked at patients treated aggressively with antiherpeticmedications at the time, the relative risk of SD was reduced by a factor of 10. It should be stressed that no investigationswere made on subjects already suffering from SD, and that those treated were the few rare cases severely affected by HSV.Nonetheless, antiherpetic medication prevented later SD development in 90% of their study group. These articles providethe first population evidence for a causal link between herpes virus infection and senile dementia.",
author = "Ruth Itzhaki and R Lathe",
year = "2018",
month = jun,
day = "19",
doi = "10.3233/JAD-180266",
language = "English",
volume = "64",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

RIS

TY - JOUR

T1 - Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link

AU - Itzhaki, Ruth

AU - Lathe, R

PY - 2018/6/19

Y1 - 2018/6/19

N2 - Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potentialtreatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al., published in the January/February2018 issue of Journal of Clinical Psychiatry) demonstrate an increased risk of subsequent senile dementia (SD) developmentin patients with acute varicella zoster (herpes zoster) infection. These articles present data highly relevant to the third, andmost important, paper—by Tzeng et al., published online in the journal Neurotherapeutics at the end of February 2018.These authors report that infection with a different herpes virus, herpes simplex virus type 1 (HSV1), leads to a similarlyincreased risk of later developing SD. Further, when the authors looked at patients treated aggressively with antiherpeticmedications at the time, the relative risk of SD was reduced by a factor of 10. It should be stressed that no investigationswere made on subjects already suffering from SD, and that those treated were the few rare cases severely affected by HSV.Nonetheless, antiherpetic medication prevented later SD development in 90% of their study group. These articles providethe first population evidence for a causal link between herpes virus infection and senile dementia.

AB - Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potentialtreatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al., published in the January/February2018 issue of Journal of Clinical Psychiatry) demonstrate an increased risk of subsequent senile dementia (SD) developmentin patients with acute varicella zoster (herpes zoster) infection. These articles present data highly relevant to the third, andmost important, paper—by Tzeng et al., published online in the journal Neurotherapeutics at the end of February 2018.These authors report that infection with a different herpes virus, herpes simplex virus type 1 (HSV1), leads to a similarlyincreased risk of later developing SD. Further, when the authors looked at patients treated aggressively with antiherpeticmedications at the time, the relative risk of SD was reduced by a factor of 10. It should be stressed that no investigationswere made on subjects already suffering from SD, and that those treated were the few rare cases severely affected by HSV.Nonetheless, antiherpetic medication prevented later SD development in 90% of their study group. These articles providethe first population evidence for a causal link between herpes virus infection and senile dementia.

U2 - 10.3233/JAD-180266

DO - 10.3233/JAD-180266

M3 - Article

VL - 64

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 2

ER -