Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Research output: Contribution to journalArticle

  • Authors:
  • S.J. Pike
  • J.E. Jones
  • J. Raftery
  • J. Clayden
  • S.J. Webb


Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Bibliographical metadata

Original languageEnglish
Pages (from-to)9580-9584
Number of pages4
JournalOrganic & biomolecular chemistry
Issue number37
StatePublished - 21 Aug 2015