Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathyCitation formats

  • External authors:
  • Shazli Azmi
  • Ioannis Petropoulos
  • Georgios Ponirakis
  • Omar Asghar
  • Uazman Alam
  • Andrew Marshall
  • Nathan Efron
  • Handrean Soran
  • Rayaz Malik

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Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathy. / Ferdousi, Maryam; Azmi, Shazli; Kalteniece, Alise; Petropoulos, Ioannis; Ponirakis, Georgios; Asghar, Omar; Alam, Uazman; Marshall, Andrew; Boulton, Andrew; Efron, Nathan; Soran, Handrean; Jeziorska, Maria; Malik, Rayaz.

In: European Journal of Neurology, 01.02.2021.

Research output: Contribution to journalArticlepeer-review

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APA

Ferdousi, M., Azmi, S., Kalteniece, A., Petropoulos, I., Ponirakis, G., Asghar, O., Alam, U., Marshall, A., Boulton, A., Efron, N., Soran, H., Jeziorska, M., & Malik, R. (2021). Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathy. European Journal of Neurology. https://doi.org/10.1111/ene.14757

Vancouver

Author

Ferdousi, Maryam ; Azmi, Shazli ; Kalteniece, Alise ; Petropoulos, Ioannis ; Ponirakis, Georgios ; Asghar, Omar ; Alam, Uazman ; Marshall, Andrew ; Boulton, Andrew ; Efron, Nathan ; Soran, Handrean ; Jeziorska, Maria ; Malik, Rayaz. / Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathy. In: European Journal of Neurology. 2021.

Bibtex

@article{d9843acfe86b49dcbf9378a07ddb3f4d,
title = "Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathy",
abstract = "Background and aim: Damage to small nociceptive fibres may contribute to painful diabetic neuropathy. We aimed to compare large and small nerve fibre measurements together with skin biopsy and corneal confocal microscopy in patients with type 1 diabetes and painful or painless diabetic neuropathy. Methods: We have assessed the McGill pain questionnaire, neuropathy disability score, vibration perception threshold, warm and cold sensation thresholds, electrophysiology, corneal confocal microscopy and skin biopsy in participants with type 1 diabetes and painful (n = 41) or painless (n = 50) diabetic neuropathy and control subjects (n = 50). Results: The duration of diabetes, body mass index, glycated haemoglobin (HbA1c), blood pressure and lipid profile did not differ between subjects with painful and painless neuropathy. Neuropathy disability score and vibration perception threshold were higher and sural nerve conduction velocity was lower, but sural nerve amplitude, peroneal nerve amplitude and conduction velocity and cold and warm sensation thresholds did not differ between patients with painful compared to painless diabetic neuropathy. However, intraepidermal nerve fibre density, corneal nerve fibre density, corneal nerve branch density and corneal nerve fibre length were significantly lower in subjects with painful compared to painless diabetic neuropathy. Conclusions: There is evidence of more severe neuropathy, particularly small fibre damage in the skin and cornea, of patients with painful compared to painless diabetic neuropathy.",
keywords = "corneal confocal microscopy, painful diabetic neuropathy, skin biopsy, small fibre pathology",
author = "Maryam Ferdousi and Shazli Azmi and Alise Kalteniece and Ioannis Petropoulos and Georgios Ponirakis and Omar Asghar and Uazman Alam and Andrew Marshall and Andrew Boulton and Nathan Efron and Handrean Soran and Maria Jeziorska and Rayaz Malik",
year = "2021",
month = feb,
day = "1",
doi = "10.1111/ene.14757",
language = "English",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "John Wiley & Sons Ltd",

}

RIS

TY - JOUR

T1 - Greater small nerve fibre damage in the skin and cornea of type 1 diabetic patients with painful compared to painless diabetic neuropathy

AU - Ferdousi, Maryam

AU - Azmi, Shazli

AU - Kalteniece, Alise

AU - Petropoulos, Ioannis

AU - Ponirakis, Georgios

AU - Asghar, Omar

AU - Alam, Uazman

AU - Marshall, Andrew

AU - Boulton, Andrew

AU - Efron, Nathan

AU - Soran, Handrean

AU - Jeziorska, Maria

AU - Malik, Rayaz

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Background and aim: Damage to small nociceptive fibres may contribute to painful diabetic neuropathy. We aimed to compare large and small nerve fibre measurements together with skin biopsy and corneal confocal microscopy in patients with type 1 diabetes and painful or painless diabetic neuropathy. Methods: We have assessed the McGill pain questionnaire, neuropathy disability score, vibration perception threshold, warm and cold sensation thresholds, electrophysiology, corneal confocal microscopy and skin biopsy in participants with type 1 diabetes and painful (n = 41) or painless (n = 50) diabetic neuropathy and control subjects (n = 50). Results: The duration of diabetes, body mass index, glycated haemoglobin (HbA1c), blood pressure and lipid profile did not differ between subjects with painful and painless neuropathy. Neuropathy disability score and vibration perception threshold were higher and sural nerve conduction velocity was lower, but sural nerve amplitude, peroneal nerve amplitude and conduction velocity and cold and warm sensation thresholds did not differ between patients with painful compared to painless diabetic neuropathy. However, intraepidermal nerve fibre density, corneal nerve fibre density, corneal nerve branch density and corneal nerve fibre length were significantly lower in subjects with painful compared to painless diabetic neuropathy. Conclusions: There is evidence of more severe neuropathy, particularly small fibre damage in the skin and cornea, of patients with painful compared to painless diabetic neuropathy.

AB - Background and aim: Damage to small nociceptive fibres may contribute to painful diabetic neuropathy. We aimed to compare large and small nerve fibre measurements together with skin biopsy and corneal confocal microscopy in patients with type 1 diabetes and painful or painless diabetic neuropathy. Methods: We have assessed the McGill pain questionnaire, neuropathy disability score, vibration perception threshold, warm and cold sensation thresholds, electrophysiology, corneal confocal microscopy and skin biopsy in participants with type 1 diabetes and painful (n = 41) or painless (n = 50) diabetic neuropathy and control subjects (n = 50). Results: The duration of diabetes, body mass index, glycated haemoglobin (HbA1c), blood pressure and lipid profile did not differ between subjects with painful and painless neuropathy. Neuropathy disability score and vibration perception threshold were higher and sural nerve conduction velocity was lower, but sural nerve amplitude, peroneal nerve amplitude and conduction velocity and cold and warm sensation thresholds did not differ between patients with painful compared to painless diabetic neuropathy. However, intraepidermal nerve fibre density, corneal nerve fibre density, corneal nerve branch density and corneal nerve fibre length were significantly lower in subjects with painful compared to painless diabetic neuropathy. Conclusions: There is evidence of more severe neuropathy, particularly small fibre damage in the skin and cornea, of patients with painful compared to painless diabetic neuropathy.

KW - corneal confocal microscopy

KW - painful diabetic neuropathy

KW - skin biopsy

KW - small fibre pathology

U2 - 10.1111/ene.14757

DO - 10.1111/ene.14757

M3 - Article

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

ER -