Graphene Nanocoating: High Quality and Stability upon Several StressorsCitation formats

  • External authors:
  • Vinicius Rosa
  • R. Malhotra
  • Shruti Vidhawan Agarwalla
  • Julien Luc Paul Morin
  • Yingmei Han
  • Ren Jie Chew
  • C.J. Seneviratne
  • Kai Soo Tan
  • Christian A Nijhuis
  • Antonio H Castro Neto

Standard

Graphene Nanocoating: High Quality and Stability upon Several Stressors. / Rosa, Vinicius; Malhotra, R.; Agarwalla, Shruti Vidhawan; Morin, Julien Luc Paul; Han, Yingmei; Chew, Ren Jie; Seneviratne, C.J.; Silikas, Nick; Tan, Kai Soo; Nijhuis, Christian A; Castro Neto, Antonio H .

In: Journal of Dental Research, Vol. 100, No. 10, 01.09.2021, p. 1169-1177.

Research output: Contribution to journalArticlepeer-review

Harvard

Rosa, V, Malhotra, R, Agarwalla, SV, Morin, JLP, Han, Y, Chew, RJ, Seneviratne, CJ, Silikas, N, Tan, KS, Nijhuis, CA & Castro Neto, AH 2021, 'Graphene Nanocoating: High Quality and Stability upon Several Stressors', Journal of Dental Research, vol. 100, no. 10, pp. 1169-1177. https://doi.org/10.1177/00220345211024526

APA

Rosa, V., Malhotra, R., Agarwalla, S. V., Morin, J. L. P., Han, Y., Chew, R. J., Seneviratne, C. J., Silikas, N., Tan, K. S., Nijhuis, C. A., & Castro Neto, A. H. (2021). Graphene Nanocoating: High Quality and Stability upon Several Stressors. Journal of Dental Research, 100(10), 1169-1177. https://doi.org/10.1177/00220345211024526

Vancouver

Rosa V, Malhotra R, Agarwalla SV, Morin JLP, Han Y, Chew RJ et al. Graphene Nanocoating: High Quality and Stability upon Several Stressors. Journal of Dental Research. 2021 Sep 1;100(10):1169-1177. https://doi.org/10.1177/00220345211024526

Author

Rosa, Vinicius ; Malhotra, R. ; Agarwalla, Shruti Vidhawan ; Morin, Julien Luc Paul ; Han, Yingmei ; Chew, Ren Jie ; Seneviratne, C.J. ; Silikas, Nick ; Tan, Kai Soo ; Nijhuis, Christian A ; Castro Neto, Antonio H . / Graphene Nanocoating: High Quality and Stability upon Several Stressors. In: Journal of Dental Research. 2021 ; Vol. 100, No. 10. pp. 1169-1177.

Bibtex

@article{b1e22edee04145e5b7e4dd8a99e0c3ae,
title = "Graphene Nanocoating: High Quality and Stability upon Several Stressors",
abstract = "Titanium implants present 2 major drawbacks—namely, the long time needed for osseointegration and the lack of inherent antimicrobial properties. Surface modifications and coatings to improve biomaterials can lose their integrity and biological potential when exposed to stressful microenvironments. Graphene nanocoating (GN) can be deposited onto actual-size dental and orthopedic implants. It has antiadhesive properties and can enhance bone formation in vivo. However, its ability to maintain structural integrity and quality when challenged by biologically relevant stresses remains largely unknown. GN was produced by chemical vapor deposition and transferred to titanium via a polymer-assisted transfer technique. GN has high inertness and did not increase expression of inflammatory markers by macrophages, even in the presence of lipopolysaccharides. It kept high coverage at the top tercile of tapered dental implant collars after installation and removal from bone substitute and pig maxilla. It also resisted microbiologically influenced corrosion, and it maintained very high coverage area and quality after prolonged exposure to biofilms and their removal by different techniques. Our findings show that GN is unresponsive to harsh and inflammatory environments and that it maintains a promising level of structural integrity on the top tercile of dental implant collars, which is the area highly affected by biofilms during the onset of implant diseases. Our findings open the avenues for the clinical studies required for the use of GN in the development of implants that have higher osteogenic potential and are less prone to implant diseases.",
keywords = "biocompatible materials, corrosion, implant dentistry/implantology, nanotechnology, prostheses and implants, titanium",
author = "Vinicius Rosa and R. Malhotra and Agarwalla, {Shruti Vidhawan} and Morin, {Julien Luc Paul} and Yingmei Han and Chew, {Ren Jie} and C.J. Seneviratne and Nick Silikas and Tan, {Kai Soo} and Nijhuis, {Christian A} and {Castro Neto}, {Antonio H}",
note = "Funding Information: The authors acknowledge the support received from the National Research Foundation Singapore and from Yu Fan Sim for the statistical analyses. Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: V. Rosa is supported by the grants from the Singapore Ministry of Education (Academic Research Fund Tier 1, R-221-000-104-114, R-221-000-132-114) and National University Health System (Open Collaborative Research Grant; October 25, 2016). Publisher Copyright: {\textcopyright} International & American Associations for Dental Research 2021.",
year = "2021",
month = sep,
day = "1",
doi = "10.1177/00220345211024526",
language = "English",
volume = "100",
pages = "1169--1177",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "Sage Publications Ltd",
number = "10",

}

RIS

TY - JOUR

T1 - Graphene Nanocoating: High Quality and Stability upon Several Stressors

AU - Rosa, Vinicius

AU - Malhotra, R.

AU - Agarwalla, Shruti Vidhawan

AU - Morin, Julien Luc Paul

AU - Han, Yingmei

AU - Chew, Ren Jie

AU - Seneviratne, C.J.

AU - Silikas, Nick

AU - Tan, Kai Soo

AU - Nijhuis, Christian A

AU - Castro Neto, Antonio H

N1 - Funding Information: The authors acknowledge the support received from the National Research Foundation Singapore and from Yu Fan Sim for the statistical analyses. Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: V. Rosa is supported by the grants from the Singapore Ministry of Education (Academic Research Fund Tier 1, R-221-000-104-114, R-221-000-132-114) and National University Health System (Open Collaborative Research Grant; October 25, 2016). Publisher Copyright: © International & American Associations for Dental Research 2021.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Titanium implants present 2 major drawbacks—namely, the long time needed for osseointegration and the lack of inherent antimicrobial properties. Surface modifications and coatings to improve biomaterials can lose their integrity and biological potential when exposed to stressful microenvironments. Graphene nanocoating (GN) can be deposited onto actual-size dental and orthopedic implants. It has antiadhesive properties and can enhance bone formation in vivo. However, its ability to maintain structural integrity and quality when challenged by biologically relevant stresses remains largely unknown. GN was produced by chemical vapor deposition and transferred to titanium via a polymer-assisted transfer technique. GN has high inertness and did not increase expression of inflammatory markers by macrophages, even in the presence of lipopolysaccharides. It kept high coverage at the top tercile of tapered dental implant collars after installation and removal from bone substitute and pig maxilla. It also resisted microbiologically influenced corrosion, and it maintained very high coverage area and quality after prolonged exposure to biofilms and their removal by different techniques. Our findings show that GN is unresponsive to harsh and inflammatory environments and that it maintains a promising level of structural integrity on the top tercile of dental implant collars, which is the area highly affected by biofilms during the onset of implant diseases. Our findings open the avenues for the clinical studies required for the use of GN in the development of implants that have higher osteogenic potential and are less prone to implant diseases.

AB - Titanium implants present 2 major drawbacks—namely, the long time needed for osseointegration and the lack of inherent antimicrobial properties. Surface modifications and coatings to improve biomaterials can lose their integrity and biological potential when exposed to stressful microenvironments. Graphene nanocoating (GN) can be deposited onto actual-size dental and orthopedic implants. It has antiadhesive properties and can enhance bone formation in vivo. However, its ability to maintain structural integrity and quality when challenged by biologically relevant stresses remains largely unknown. GN was produced by chemical vapor deposition and transferred to titanium via a polymer-assisted transfer technique. GN has high inertness and did not increase expression of inflammatory markers by macrophages, even in the presence of lipopolysaccharides. It kept high coverage at the top tercile of tapered dental implant collars after installation and removal from bone substitute and pig maxilla. It also resisted microbiologically influenced corrosion, and it maintained very high coverage area and quality after prolonged exposure to biofilms and their removal by different techniques. Our findings show that GN is unresponsive to harsh and inflammatory environments and that it maintains a promising level of structural integrity on the top tercile of dental implant collars, which is the area highly affected by biofilms during the onset of implant diseases. Our findings open the avenues for the clinical studies required for the use of GN in the development of implants that have higher osteogenic potential and are less prone to implant diseases.

KW - biocompatible materials

KW - corrosion

KW - implant dentistry/implantology

KW - nanotechnology

KW - prostheses and implants

KW - titanium

U2 - 10.1177/00220345211024526

DO - 10.1177/00220345211024526

M3 - Article

VL - 100

SP - 1169

EP - 1177

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 10

ER -