Graphene materials as 2D non-viral gene transfer vector platformsCitation formats

Standard

Graphene materials as 2D non-viral gene transfer vector platforms. / Kostarelos, Kostas; Vincent, Melissa; De Lazaro Del Rey, Irene.

In: Gene Therapy, Vol. 24, 2017, p. 123-132.

Research output: Contribution to journalArticle

Harvard

Kostarelos, K, Vincent, M & De Lazaro Del Rey, I 2017, 'Graphene materials as 2D non-viral gene transfer vector platforms' Gene Therapy, vol. 24, pp. 123-132. https://doi.org/10.1038/gt.2016.79

APA

Kostarelos, K., Vincent, M., & De Lazaro Del Rey, I. (2017). Graphene materials as 2D non-viral gene transfer vector platforms. Gene Therapy, 24, 123-132. https://doi.org/10.1038/gt.2016.79

Vancouver

Author

Kostarelos, Kostas ; Vincent, Melissa ; De Lazaro Del Rey, Irene. / Graphene materials as 2D non-viral gene transfer vector platforms. In: Gene Therapy. 2017 ; Vol. 24. pp. 123-132.

Bibtex

@article{191dd800b9c2424d81c67314fbe453cf,
title = "Graphene materials as 2D non-viral gene transfer vector platforms",
abstract = "Advances in genomics and gene therapy could offer solutions to many diseases that remain incurable today, however one of the critical reasons halting clinical progress is due to the difficulty in designing efficient and safe delivery vectors for the appropriate genetic cargo. Safety and large-scale production concerns counter-balance the high gene transfer efficiency achieved with viral vectors, while non-viral strategies have yet to become sufficiently efficient. The extraordinary physicochemical, optical and photothermal properties of graphene-based materials (GBMs) could offer two-dimensional (2D) components for the design of nucleic acid carrier systems. We discuss here such properties and their implications for the optimization of gene delivery. While the design of such vectors is still in its infancy, we provide here an exhaustive and up-to-date analysis of the studies that have explored GBMs as gene transfer vectors, focusing on the functionalization strategies followed to improve vector performance and on the biological effects attained.",
author = "Kostas Kostarelos and Melissa Vincent and {De Lazaro Del Rey}, Irene",
year = "2017",
doi = "10.1038/gt.2016.79",
language = "English",
volume = "24",
pages = "123--132",
journal = "Gene Therapy",
issn = "0969-7128",
publisher = "Springer Nature",

}

RIS

TY - JOUR

T1 - Graphene materials as 2D non-viral gene transfer vector platforms

AU - Kostarelos, Kostas

AU - Vincent, Melissa

AU - De Lazaro Del Rey, Irene

PY - 2017

Y1 - 2017

N2 - Advances in genomics and gene therapy could offer solutions to many diseases that remain incurable today, however one of the critical reasons halting clinical progress is due to the difficulty in designing efficient and safe delivery vectors for the appropriate genetic cargo. Safety and large-scale production concerns counter-balance the high gene transfer efficiency achieved with viral vectors, while non-viral strategies have yet to become sufficiently efficient. The extraordinary physicochemical, optical and photothermal properties of graphene-based materials (GBMs) could offer two-dimensional (2D) components for the design of nucleic acid carrier systems. We discuss here such properties and their implications for the optimization of gene delivery. While the design of such vectors is still in its infancy, we provide here an exhaustive and up-to-date analysis of the studies that have explored GBMs as gene transfer vectors, focusing on the functionalization strategies followed to improve vector performance and on the biological effects attained.

AB - Advances in genomics and gene therapy could offer solutions to many diseases that remain incurable today, however one of the critical reasons halting clinical progress is due to the difficulty in designing efficient and safe delivery vectors for the appropriate genetic cargo. Safety and large-scale production concerns counter-balance the high gene transfer efficiency achieved with viral vectors, while non-viral strategies have yet to become sufficiently efficient. The extraordinary physicochemical, optical and photothermal properties of graphene-based materials (GBMs) could offer two-dimensional (2D) components for the design of nucleic acid carrier systems. We discuss here such properties and their implications for the optimization of gene delivery. While the design of such vectors is still in its infancy, we provide here an exhaustive and up-to-date analysis of the studies that have explored GBMs as gene transfer vectors, focusing on the functionalization strategies followed to improve vector performance and on the biological effects attained.

U2 - 10.1038/gt.2016.79

DO - 10.1038/gt.2016.79

M3 - Article

VL - 24

SP - 123

EP - 132

JO - Gene Therapy

JF - Gene Therapy

SN - 0969-7128

ER -