Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?Citation formats

  • External authors:
  • R. Cooper
  • S. Sarioǧlu
  • S. Sökmen
  • M. Füzün
  • A. Küpelioǧlu
  • H. Valentine
  • I. B. Görken
  • R. Airley

Standard

Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma? / Cooper, R.; Sarioǧlu, S.; Sökmen, S.; Füzün, M.; Küpelioǧlu, A.; Valentine, H.; Görken, I. B.; Airley, R.; West, C.

In: British Journal of Cancer, Vol. 89, No. 5, 01.09.2003, p. 870-876.

Research output: Contribution to journalArticlepeer-review

Harvard

Cooper, R, Sarioǧlu, S, Sökmen, S, Füzün, M, Küpelioǧlu, A, Valentine, H, Görken, IB, Airley, R & West, C 2003, 'Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?', British Journal of Cancer, vol. 89, no. 5, pp. 870-876. https://doi.org/10.1038/sj.bjc.6601202

APA

Cooper, R., Sarioǧlu, S., Sökmen, S., Füzün, M., Küpelioǧlu, A., Valentine, H., Görken, I. B., Airley, R., & West, C. (2003). Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma? British Journal of Cancer, 89(5), 870-876. https://doi.org/10.1038/sj.bjc.6601202

Vancouver

Cooper R, Sarioǧlu S, Sökmen S, Füzün M, Küpelioǧlu A, Valentine H et al. Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma? British Journal of Cancer. 2003 Sep 1;89(5):870-876. https://doi.org/10.1038/sj.bjc.6601202

Author

Cooper, R. ; Sarioǧlu, S. ; Sökmen, S. ; Füzün, M. ; Küpelioǧlu, A. ; Valentine, H. ; Görken, I. B. ; Airley, R. ; West, C. / Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?. In: British Journal of Cancer. 2003 ; Vol. 89, No. 5. pp. 870-876.

Bibtex

@article{af2250c4cc284ea4b246b3a59999e17d,
title = "Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?",
abstract = "The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, 50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P = 0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r = 0.81), but a significant relationship with outcome was only found in the deep part (P = 0.003 vs P = 0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy. {\textcopyright} 2003 Cancer Research UK.",
keywords = "GLUT-1, Hypoxia, Rectal cancer",
author = "R. Cooper and S. Sarioǧlu and S. S{\"o}kmen and M. F{\"u}z{\"u}n and A. K{\"u}pelioǧlu and H. Valentine and G{\"o}rken, {I. B.} and R. Airley and C. West",
year = "2003",
month = sep,
day = "1",
doi = "10.1038/sj.bjc.6601202",
language = "English",
volume = "89",
pages = "870--876",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Glucose transporter-1 (GLUT-1): A potential marker of prognosis in rectal carcinoma?

AU - Cooper, R.

AU - Sarioǧlu, S.

AU - Sökmen, S.

AU - Füzün, M.

AU - Küpelioǧlu, A.

AU - Valentine, H.

AU - Görken, I. B.

AU - Airley, R.

AU - West, C.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, 50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P = 0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r = 0.81), but a significant relationship with outcome was only found in the deep part (P = 0.003 vs P = 0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy. © 2003 Cancer Research UK.

AB - The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, 50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P = 0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r = 0.81), but a significant relationship with outcome was only found in the deep part (P = 0.003 vs P = 0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy. © 2003 Cancer Research UK.

KW - GLUT-1

KW - Hypoxia

KW - Rectal cancer

U2 - 10.1038/sj.bjc.6601202

DO - 10.1038/sj.bjc.6601202

M3 - Article

VL - 89

SP - 870

EP - 876

JO - BJC

JF - BJC

SN - 0007-0920

IS - 5

ER -