Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Research output: Contribution to journalArticle

  • Authors:
  • Jayaram Vijayakrishnan
  • James Studd
  • Peter Broderick
  • Ben Kinnersley
  • Amy Holroyd
  • Philip J. Law
  • Rajiv Kumar
  • James M. Allan
  • Christine J. Harrison
  • Anthony V. Moorman
  • Ajay Vora
  • Eve Roman
  • Sivaramakrishna Rachakonda
  • Sally E. Kinsey
  • Eamonn Sheridan
  • Pamela D. Thompson
  • Julie A. Irving
  • Rolf Koehler
  • Per Hoffmann
  • Markus M. Nöthen
  • Stefanie Heilmann-Heimbach
  • Karl Heinz Jöckel
  • Douglas F. Easton
  • Paul D.P. Pharaoh
  • Alison M. Dunning
  • Julian Peto
  • Frederico Canzian
  • Anthony Swerdlow
  • Rosalind A. Eeles
  • ZSofia Kote-Jarai
  • Kenneth Muir
  • Nora Pashayan
  • Mel Greaves
  • Martin Zimmerman
  • Claus R. Bartram
  • Martin Schrappe
  • Martin Stanulla
  • Kari Hemminki
  • Richard S. Houlston
  • Brian E. Henderson
  • Christopher A. Haiman
  • Sara Benlloch
  • Fredrick R. Schumacher
  • Ali Amin Al Olama
  • Sonja I. Berndt
  • David V. Conti
  • Fredrik Wiklund
  • Stephen Chanock
  • Catharine West
  • Paul A. Townsend
  • The PRACTICAL Consortium

Abstract

Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.

Bibliographical metadata

Original languageEnglish
Article number1340
JournalNature Communications
Volume9
Issue number1
Early online date9 Apr 2018
DOIs
Publication statusPublished - 2018

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