Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations.Citation formats

  • External authors:
  • Blazenka Kljaic-Bukvic
  • Mario Blekic
  • Neda Aberle
  • Aida Semic-Jusufagic
  • Danielle Belgrave
  • Adnan Custovic

Standard

Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations. / Kljaic-Bukvic, Blazenka; Blekic, Mario; Aberle, Neda; Curtin, John A; Hankinson, Jenny; Semic-Jusufagic, Aida; Belgrave, Danielle; Simpson, Angela; Custovic, Adnan.

In: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Vol. 25, No. 6, 10.2014, p. 552-7.

Research output: Contribution to journalArticlepeer-review

Harvard

Kljaic-Bukvic, B, Blekic, M, Aberle, N, Curtin, JA, Hankinson, J, Semic-Jusufagic, A, Belgrave, D, Simpson, A & Custovic, A 2014, 'Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations.', Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, vol. 25, no. 6, pp. 552-7. https://doi.org/10.1111/pai.12258

APA

Kljaic-Bukvic, B., Blekic, M., Aberle, N., Curtin, J. A., Hankinson, J., Semic-Jusufagic, A., Belgrave, D., Simpson, A., & Custovic, A. (2014). Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(6), 552-7. https://doi.org/10.1111/pai.12258

Vancouver

Kljaic-Bukvic B, Blekic M, Aberle N, Curtin JA, Hankinson J, Semic-Jusufagic A et al. Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2014 Oct;25(6):552-7. https://doi.org/10.1111/pai.12258

Author

Kljaic-Bukvic, Blazenka ; Blekic, Mario ; Aberle, Neda ; Curtin, John A ; Hankinson, Jenny ; Semic-Jusufagic, Aida ; Belgrave, Danielle ; Simpson, Angela ; Custovic, Adnan. / Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations. In: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2014 ; Vol. 25, No. 6. pp. 552-7.

Bibtex

@article{ae97d926b8bc4b6fa01190a0f0e5e427,
title = "Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations.",
abstract = "BACKGROUND: We investigated the interaction between genetic variants in endotoxin signalling pathway and domestic endotoxin exposure in relation to asthma presence, and amongst children with asthma, we explored the association of these genetic variants and endotoxin exposure with hospital admissions due to asthma exacerbations. METHODS: In a case-control study, we analysed data from 824 children (417 asthmatics, 407 controls; age 5-18 yr). Amongst asthmatics, we extracted data on hospitalization for asthma exacerbation from medical records. Endotoxin exposure was measured in dust samples collected from homes. We included 26 single-nucleotide polymorphisms (SNPs) in the final analysis (5 CD14, 7LY96 and 14 TLR4). RESULTS: Two variants remained significantly associated with hospital admissions with asthma exacerbations after correction for multiple testing: for CD14 SNP rs5744455, carriers of T allele had decreased risk of repeated hospital admissions compared with homozygotes for C allele [OR (95% CI), 0.42 (0.25-0.88), p = 0.01, False Discovery Rate (FDR) p = 0.02]; for LY96 SNP rs17226566, C-allele carriers were at a lower risk of hospital admissions compared with T-allele homozygotes [0.59 (0.38-0.90), p = 0.01, FDR p = 0.04]. We observed two interactions between SNPs in CD14 and LY96 with environmental endotoxin exposure in relation to hospital admissions due to asthma exacerbation which remained significant after correction for multiple testing (CD14 SNPs rs2915863 and LY96 SNP rs17226566). CONCLUSION: Amongst children with asthma, genetic variants in CD14 and LY96 may increase the risk of hospital admissions with acute exacerbations. Polymorphisms in endotoxin pathway interact with domestic endotoxin exposure in further modification of the risk of hospitalization.",
keywords = "CD14, LY96, TLR4, asthma, children, endotoxin, gene-environment interactions",
author = "Blazenka Kljaic-Bukvic and Mario Blekic and Neda Aberle and Curtin, {John A} and Jenny Hankinson and Aida Semic-Jusufagic and Danielle Belgrave and Angela Simpson and Adnan Custovic",
note = "MR/K002449/1, Medical Research Council, United Kingdom",
year = "2014",
month = oct,
doi = "10.1111/pai.12258",
language = "English",
volume = "25",
pages = "552--7",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "6",

}

RIS

TY - JOUR

T1 - Genetic variants in endotoxin signalling pathway, domestic endotoxin exposure and asthma exacerbations.

AU - Kljaic-Bukvic, Blazenka

AU - Blekic, Mario

AU - Aberle, Neda

AU - Curtin, John A

AU - Hankinson, Jenny

AU - Semic-Jusufagic, Aida

AU - Belgrave, Danielle

AU - Simpson, Angela

AU - Custovic, Adnan

N1 - MR/K002449/1, Medical Research Council, United Kingdom

PY - 2014/10

Y1 - 2014/10

N2 - BACKGROUND: We investigated the interaction between genetic variants in endotoxin signalling pathway and domestic endotoxin exposure in relation to asthma presence, and amongst children with asthma, we explored the association of these genetic variants and endotoxin exposure with hospital admissions due to asthma exacerbations. METHODS: In a case-control study, we analysed data from 824 children (417 asthmatics, 407 controls; age 5-18 yr). Amongst asthmatics, we extracted data on hospitalization for asthma exacerbation from medical records. Endotoxin exposure was measured in dust samples collected from homes. We included 26 single-nucleotide polymorphisms (SNPs) in the final analysis (5 CD14, 7LY96 and 14 TLR4). RESULTS: Two variants remained significantly associated with hospital admissions with asthma exacerbations after correction for multiple testing: for CD14 SNP rs5744455, carriers of T allele had decreased risk of repeated hospital admissions compared with homozygotes for C allele [OR (95% CI), 0.42 (0.25-0.88), p = 0.01, False Discovery Rate (FDR) p = 0.02]; for LY96 SNP rs17226566, C-allele carriers were at a lower risk of hospital admissions compared with T-allele homozygotes [0.59 (0.38-0.90), p = 0.01, FDR p = 0.04]. We observed two interactions between SNPs in CD14 and LY96 with environmental endotoxin exposure in relation to hospital admissions due to asthma exacerbation which remained significant after correction for multiple testing (CD14 SNPs rs2915863 and LY96 SNP rs17226566). CONCLUSION: Amongst children with asthma, genetic variants in CD14 and LY96 may increase the risk of hospital admissions with acute exacerbations. Polymorphisms in endotoxin pathway interact with domestic endotoxin exposure in further modification of the risk of hospitalization.

AB - BACKGROUND: We investigated the interaction between genetic variants in endotoxin signalling pathway and domestic endotoxin exposure in relation to asthma presence, and amongst children with asthma, we explored the association of these genetic variants and endotoxin exposure with hospital admissions due to asthma exacerbations. METHODS: In a case-control study, we analysed data from 824 children (417 asthmatics, 407 controls; age 5-18 yr). Amongst asthmatics, we extracted data on hospitalization for asthma exacerbation from medical records. Endotoxin exposure was measured in dust samples collected from homes. We included 26 single-nucleotide polymorphisms (SNPs) in the final analysis (5 CD14, 7LY96 and 14 TLR4). RESULTS: Two variants remained significantly associated with hospital admissions with asthma exacerbations after correction for multiple testing: for CD14 SNP rs5744455, carriers of T allele had decreased risk of repeated hospital admissions compared with homozygotes for C allele [OR (95% CI), 0.42 (0.25-0.88), p = 0.01, False Discovery Rate (FDR) p = 0.02]; for LY96 SNP rs17226566, C-allele carriers were at a lower risk of hospital admissions compared with T-allele homozygotes [0.59 (0.38-0.90), p = 0.01, FDR p = 0.04]. We observed two interactions between SNPs in CD14 and LY96 with environmental endotoxin exposure in relation to hospital admissions due to asthma exacerbation which remained significant after correction for multiple testing (CD14 SNPs rs2915863 and LY96 SNP rs17226566). CONCLUSION: Amongst children with asthma, genetic variants in CD14 and LY96 may increase the risk of hospital admissions with acute exacerbations. Polymorphisms in endotoxin pathway interact with domestic endotoxin exposure in further modification of the risk of hospitalization.

KW - CD14

KW - LY96

KW - TLR4

KW - asthma

KW - children

KW - endotoxin

KW - gene-environment interactions

U2 - 10.1111/pai.12258

DO - 10.1111/pai.12258

M3 - Article

C2 - 24902762

VL - 25

SP - 552

EP - 557

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 6

ER -