Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Research output: Contribution to journalArticle

  • External authors:
  • Mira M. Wouters
  • Diether Lambrechts
  • Michael Knapp
  • Isabelle Cleynen
  • Lars Agréus
  • Aldona Dlugosz
  • Peter Thelin Schmidt
  • Jonas Halfvarson
  • Magnus Simrén
  • Bodil Ohlsson
  • Pontus Karling
  • Sander Van Wanrooy
  • Stéphanie Mondelaers
  • Severine Vermeire
  • Greger Lindberg
  • Robin Spiller
  • George Dukes
  • Mauro D'Amato
  • Guy Boeckxstaens

Abstract

Objective: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS patients, 639 controls). 33 SNPs with P uncorrected

Bibliographical metadata

Original languageEnglish
Pages (from-to)1103-1111
Number of pages8
JournalGut
Volume63
Issue number7
DOIs
Publication statusPublished - 2014