Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individualsCitation formats

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Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. / 23andMe Research Team ; Pendleton, Neil.

In: Nature Genetics, Vol. 50, No. 8, 08.2018, p. 1112-1121.

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@article{6e6316206c1a4c089f4e3fbbec13ed40,
title = "Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals",
abstract = "Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3{\%} in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13{\%} of the variance in educational attainment and 7-10{\%} of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.",
author = "{23andMe Research Team} and Lee, {James J} and Robbee Wedow and Aysu Okbay and Edward Kong and Omeed Maghzian and Meghan Zacher and Nguyen-Viet, {Tuan Anh} and Peter Bowers and Julia Sidorenko and {Karlsson Linn{\'e}r}, Richard and Fontana, {Mark Alan} and Tushar Kundu and Chanwook Lee and Hui Li and Ruoxi Li and Rebecca Royer and Timshel, {Pascal N} and Walters, {Raymond K} and Willoughby, {Emily A} and Lo{\"i}c Yengo and Maris Alver and Yanchun Bao and Clark, {David W} and Day, {Felix R} and Furlotte, {Nicholas A} and Joshi, {Peter K} and Kemper, {Kathryn E} and Aaron Kleinman and Claudia Langenberg and Reedik M{\"a}gi and Trampush, {Joey W} and Verma, {Shefali Setia} and Yang Wu and Max Lam and Zhao, {Jing Hua} and Zhili Zheng and Boardman, {Jason D} and Harry Campbell and Jeremy Freese and Harris, {Kathleen Mullan} and Caroline Hayward and Pamela Herd and Meena Kumari and Todd Lencz and Jian'an Luan and Malhotra, {Anil K} and Andres Metspalu and Wilson, {James F} and Robinson, {Matthew R} and Jian Yang and Neil Pendleton",
year = "2018",
month = "8",
doi = "10.1038/s41588-018-0147-3",
language = "English",
volume = "50",
pages = "1112--1121",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Springer Nature",
number = "8",

}

RIS

TY - JOUR

T1 - Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

AU - 23andMe Research Team

AU - Lee, James J

AU - Wedow, Robbee

AU - Okbay, Aysu

AU - Kong, Edward

AU - Maghzian, Omeed

AU - Zacher, Meghan

AU - Nguyen-Viet, Tuan Anh

AU - Bowers, Peter

AU - Sidorenko, Julia

AU - Karlsson Linnér, Richard

AU - Fontana, Mark Alan

AU - Kundu, Tushar

AU - Lee, Chanwook

AU - Li, Hui

AU - Li, Ruoxi

AU - Royer, Rebecca

AU - Timshel, Pascal N

AU - Walters, Raymond K

AU - Willoughby, Emily A

AU - Yengo, Loïc

AU - Alver, Maris

AU - Bao, Yanchun

AU - Clark, David W

AU - Day, Felix R

AU - Furlotte, Nicholas A

AU - Joshi, Peter K

AU - Kemper, Kathryn E

AU - Kleinman, Aaron

AU - Langenberg, Claudia

AU - Mägi, Reedik

AU - Trampush, Joey W

AU - Verma, Shefali Setia

AU - Wu, Yang

AU - Lam, Max

AU - Zhao, Jing Hua

AU - Zheng, Zhili

AU - Boardman, Jason D

AU - Campbell, Harry

AU - Freese, Jeremy

AU - Harris, Kathleen Mullan

AU - Hayward, Caroline

AU - Herd, Pamela

AU - Kumari, Meena

AU - Lencz, Todd

AU - Luan, Jian'an

AU - Malhotra, Anil K

AU - Metspalu, Andres

AU - Wilson, James F

AU - Robinson, Matthew R

AU - Yang, Jian

AU - Pendleton, Neil

PY - 2018/8

Y1 - 2018/8

N2 - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

AB - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.

U2 - 10.1038/s41588-018-0147-3

DO - 10.1038/s41588-018-0147-3

M3 - Article

VL - 50

SP - 1112

EP - 1121

JO - Nature Genetics

T2 - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -