GABA modulates frequency-dependent plasticity in humansCitation formats

  • External authors:
  • Faezeh S. Nezhad
  • Marcelo A. Montemurro
  • Wael El-deredy

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GABA modulates frequency-dependent plasticity in humans. / Lea-carnall, Caroline A.; Williams, Stephen R.; Nezhad, Faezeh S.; Trujillo-barreto, Nelson J.; Montemurro, Marcelo A.; El-deredy, Wael; Parkes, Laura M.

In: iScience, 08.10.2020, p. 101657.

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@article{e6d5135625cb45048c07ef40232bb263,
title = "GABA modulates frequency-dependent plasticity in humans",
abstract = "Frequency-dependent reorganisation of the primary somatosensory cortex, together with perceptual changes, arise following repetitive sensory stimulation. Here we investigate the role of GABA in this process. We co-stimulated two finger-tips and measured GABA and Glx using MR spectroscopy at the beginning and end of the stimulation. Participants performed a perceptual learning task before and after stimulation. There were 2 sessions with stimulation frequency either at or above the resonance frequency of the somatosensory cortex (23, and 39 Hz respectively). Perceptual learning occurred following above-resonance stimulation only, while GABA reduced during this condition. Lower levels of early GABA were associated with greater perceptual learning. One possible mechanism underlying this finding is that cortical disinhibition {\textquoteleft}unmasks{\textquoteright} lateral connections within the cortex to permit adaptation to the sensory environment. These results provide evidence in humans for a frequency-dependent inhibitory mechanism underlying learning, and suggests a mechanism based approach for optimising neurostimulation frequency.",
author = "Lea-carnall, {Caroline A.} and Williams, {Stephen R.} and Nezhad, {Faezeh S.} and Trujillo-barreto, {Nelson J.} and Montemurro, {Marcelo A.} and Wael El-deredy and Parkes, {Laura M.}",
year = "2020",
month = oct,
day = "8",
doi = "10.1016/j.isci.2020.101657",
language = "English",
pages = "101657",
journal = "iScience",
issn = "2589-0042",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - GABA modulates frequency-dependent plasticity in humans

AU - Lea-carnall, Caroline A.

AU - Williams, Stephen R.

AU - Nezhad, Faezeh S.

AU - Trujillo-barreto, Nelson J.

AU - Montemurro, Marcelo A.

AU - El-deredy, Wael

AU - Parkes, Laura M.

PY - 2020/10/8

Y1 - 2020/10/8

N2 - Frequency-dependent reorganisation of the primary somatosensory cortex, together with perceptual changes, arise following repetitive sensory stimulation. Here we investigate the role of GABA in this process. We co-stimulated two finger-tips and measured GABA and Glx using MR spectroscopy at the beginning and end of the stimulation. Participants performed a perceptual learning task before and after stimulation. There were 2 sessions with stimulation frequency either at or above the resonance frequency of the somatosensory cortex (23, and 39 Hz respectively). Perceptual learning occurred following above-resonance stimulation only, while GABA reduced during this condition. Lower levels of early GABA were associated with greater perceptual learning. One possible mechanism underlying this finding is that cortical disinhibition ‘unmasks’ lateral connections within the cortex to permit adaptation to the sensory environment. These results provide evidence in humans for a frequency-dependent inhibitory mechanism underlying learning, and suggests a mechanism based approach for optimising neurostimulation frequency.

AB - Frequency-dependent reorganisation of the primary somatosensory cortex, together with perceptual changes, arise following repetitive sensory stimulation. Here we investigate the role of GABA in this process. We co-stimulated two finger-tips and measured GABA and Glx using MR spectroscopy at the beginning and end of the stimulation. Participants performed a perceptual learning task before and after stimulation. There were 2 sessions with stimulation frequency either at or above the resonance frequency of the somatosensory cortex (23, and 39 Hz respectively). Perceptual learning occurred following above-resonance stimulation only, while GABA reduced during this condition. Lower levels of early GABA were associated with greater perceptual learning. One possible mechanism underlying this finding is that cortical disinhibition ‘unmasks’ lateral connections within the cortex to permit adaptation to the sensory environment. These results provide evidence in humans for a frequency-dependent inhibitory mechanism underlying learning, and suggests a mechanism based approach for optimising neurostimulation frequency.

U2 - 10.1016/j.isci.2020.101657

DO - 10.1016/j.isci.2020.101657

M3 - Article

SP - 101657

JO - iScience

JF - iScience

SN - 2589-0042

ER -