Future Therapeutic Directions for the Treatment of PsoriasisCitation formats
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Future Therapeutic Directions for the Treatment of Psoriasis. / Warren, R. B.; Griffiths, C. E M.
In: Actas Dermo-Sifiliograficas, Vol. 100, No. 2, 12.2009, p. 28-31.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Future Therapeutic Directions for the Treatment of Psoriasis
AU - Warren, R. B.
AU - Griffiths, C. E M
PY - 2009/12
Y1 - 2009/12
N2 - The future management of psoriasis will depend on a number of distinct but ultimately inter-related strands of evidence, these are: (i) the interplay of genes and environment and the characterisation of psoriasis phenotypes; (ii) the role of pharmacogenetics in personalised healthcare; (iii) the translation of basic scientific discovery of relevant immune and angiogenic pathways into targeted biologic and small molecule therapies; and (iv) the recognition that the management of any chronic disease is enhanced by an understanding of psychosocial issues. A reductionist approach to development of new therapies will be paramount but serendipity and the prepared mind will contribute, as they have always done. © 2009 Academia Española de Dermatología y Venereología.
AB - The future management of psoriasis will depend on a number of distinct but ultimately inter-related strands of evidence, these are: (i) the interplay of genes and environment and the characterisation of psoriasis phenotypes; (ii) the role of pharmacogenetics in personalised healthcare; (iii) the translation of basic scientific discovery of relevant immune and angiogenic pathways into targeted biologic and small molecule therapies; and (iv) the recognition that the management of any chronic disease is enhanced by an understanding of psychosocial issues. A reductionist approach to development of new therapies will be paramount but serendipity and the prepared mind will contribute, as they have always done. © 2009 Academia Española de Dermatología y Venereología.
KW - biologic therapy
KW - biologics
KW - personalised medicine
KW - pharmacogenetics
KW - phenotypes
KW - psoriasis
U2 - 10.1016/S0001-7310(09)73375-7
DO - 10.1016/S0001-7310(09)73375-7
M3 - Article
C2 - 20096159
VL - 100
SP - 28
EP - 31
JO - Actas Dermo-Sifiliograficas
JF - Actas Dermo-Sifiliograficas
SN - 0001-7310
IS - 2
ER -