Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal responseCitation formats

  • External authors:
  • Monica Sueiro Olivares
  • Jennifer Scott
  • Dunja Petrovic
  • Emilia Kouroussis
  • Jasmina Zivanovic
  • Yidong Yu
  • Marlene Strobel
  • Cristina Cunha
  • Rachael Fortune-Grant
  • Sina Thusek
  • Paul Bowyer
  • Andreas Beilhack
  • Agostinho Carvalho
  • Milos R. Filipovic

Standard

Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response. / Sueiro Olivares, Monica; Scott, Jennifer; Gago, Sara; Petrovic, Dunja; Kouroussis, Emilia; Zivanovic, Jasmina; Yu, Yidong; Strobel, Marlene; Cunha, Cristina; Thomson, Darren; Fortune-Grant, Rachael; Thusek, Sina; Bowyer, Paul; Beilhack, Andreas; Carvalho, Agostinho; Bignell, Elaine; Filipovic, Milos R.; Amich Elias, Jorge.

In: PL o S Biology, 27.04.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Sueiro Olivares, M, Scott, J, Gago, S, Petrovic, D, Kouroussis, E, Zivanovic, J, Yu, Y, Strobel, M, Cunha, C, Thomson, D, Fortune-Grant, R, Thusek, S, Bowyer, P, Beilhack, A, Carvalho, A, Bignell, E, Filipovic, MR & Amich Elias, J 2021, 'Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response', PL o S Biology.

APA

Sueiro Olivares, M., Scott, J., Gago, S., Petrovic, D., Kouroussis, E., Zivanovic, J., Yu, Y., Strobel, M., Cunha, C., Thomson, D., Fortune-Grant, R., Thusek, S., Bowyer, P., Beilhack, A., Carvalho, A., Bignell, E., Filipovic, M. R., & Amich Elias, J. (Accepted/In press). Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response. PL o S Biology.

Vancouver

Sueiro Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J et al. Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response. PL o S Biology. 2021 Apr 27.

Author

Sueiro Olivares, Monica ; Scott, Jennifer ; Gago, Sara ; Petrovic, Dunja ; Kouroussis, Emilia ; Zivanovic, Jasmina ; Yu, Yidong ; Strobel, Marlene ; Cunha, Cristina ; Thomson, Darren ; Fortune-Grant, Rachael ; Thusek, Sina ; Bowyer, Paul ; Beilhack, Andreas ; Carvalho, Agostinho ; Bignell, Elaine ; Filipovic, Milos R. ; Amich Elias, Jorge. / Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response. In: PL o S Biology. 2021.

Bibtex

@article{961d8f25369d488fb7aa2ebd675d48b8,
title = "Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response",
abstract = "Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary 29 infections, termed aspergilloses, in individuals suffering immune imbalances or 30 underlying lung conditions. As rapid adaptation to stress is crucial for the outcome of 31 the host-pathogen interplay, here we investigated the role of the versatile post-32 translational modification persulfidation for both fungal virulence and antifungal host 33 defence. We show that an A. fumigatus mutant with low persulfidation levels is more 34 susceptible to host-mediated killing and displays reduced virulence in murine models of 35 infection. Additionally, we found that a single-nucleotide-polymorphism (SNP) in the 36 human gene encoding cystathionine-γ-lyase causes a reduction in cellular persulfidation 37 and correlates with a predisposition of hematopoietic-stem-cell-transplant recipients to 38 invasive pulmonary aspergillosis, as correct levels of persulfidation are required for 39 optimal antifungal activity of recipients{\textquoteright} lung-resident host cells. Importantly, the levels 40 of host persulfidation determine the levels of fungal persulfidation, ultimately reflecting 41 a host-pathogen functional correlation and highlighting a potential new therapeutic 42 target for the treatment of aspergillosis.",
author = "{Sueiro Olivares}, Monica and Jennifer Scott and Sara Gago and Dunja Petrovic and Emilia Kouroussis and Jasmina Zivanovic and Yidong Yu and Marlene Strobel and Cristina Cunha and Darren Thomson and Rachael Fortune-Grant and Sina Thusek and Paul Bowyer and Andreas Beilhack and Agostinho Carvalho and Elaine Bignell and Filipovic, {Milos R.} and {Amich Elias}, Jorge",
year = "2021",
month = apr,
day = "27",
language = "English",
journal = "PL o S Biology",
issn = "1545-7885",
publisher = "Public Library of Science",

}

RIS

TY - JOUR

T1 - Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response

AU - Sueiro Olivares, Monica

AU - Scott, Jennifer

AU - Gago, Sara

AU - Petrovic, Dunja

AU - Kouroussis, Emilia

AU - Zivanovic, Jasmina

AU - Yu, Yidong

AU - Strobel, Marlene

AU - Cunha, Cristina

AU - Thomson, Darren

AU - Fortune-Grant, Rachael

AU - Thusek, Sina

AU - Bowyer, Paul

AU - Beilhack, Andreas

AU - Carvalho, Agostinho

AU - Bignell, Elaine

AU - Filipovic, Milos R.

AU - Amich Elias, Jorge

PY - 2021/4/27

Y1 - 2021/4/27

N2 - Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary 29 infections, termed aspergilloses, in individuals suffering immune imbalances or 30 underlying lung conditions. As rapid adaptation to stress is crucial for the outcome of 31 the host-pathogen interplay, here we investigated the role of the versatile post-32 translational modification persulfidation for both fungal virulence and antifungal host 33 defence. We show that an A. fumigatus mutant with low persulfidation levels is more 34 susceptible to host-mediated killing and displays reduced virulence in murine models of 35 infection. Additionally, we found that a single-nucleotide-polymorphism (SNP) in the 36 human gene encoding cystathionine-γ-lyase causes a reduction in cellular persulfidation 37 and correlates with a predisposition of hematopoietic-stem-cell-transplant recipients to 38 invasive pulmonary aspergillosis, as correct levels of persulfidation are required for 39 optimal antifungal activity of recipients’ lung-resident host cells. Importantly, the levels 40 of host persulfidation determine the levels of fungal persulfidation, ultimately reflecting 41 a host-pathogen functional correlation and highlighting a potential new therapeutic 42 target for the treatment of aspergillosis.

AB - Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary 29 infections, termed aspergilloses, in individuals suffering immune imbalances or 30 underlying lung conditions. As rapid adaptation to stress is crucial for the outcome of 31 the host-pathogen interplay, here we investigated the role of the versatile post-32 translational modification persulfidation for both fungal virulence and antifungal host 33 defence. We show that an A. fumigatus mutant with low persulfidation levels is more 34 susceptible to host-mediated killing and displays reduced virulence in murine models of 35 infection. Additionally, we found that a single-nucleotide-polymorphism (SNP) in the 36 human gene encoding cystathionine-γ-lyase causes a reduction in cellular persulfidation 37 and correlates with a predisposition of hematopoietic-stem-cell-transplant recipients to 38 invasive pulmonary aspergillosis, as correct levels of persulfidation are required for 39 optimal antifungal activity of recipients’ lung-resident host cells. Importantly, the levels 40 of host persulfidation determine the levels of fungal persulfidation, ultimately reflecting 41 a host-pathogen functional correlation and highlighting a potential new therapeutic 42 target for the treatment of aspergillosis.

M3 - Article

JO - PL o S Biology

JF - PL o S Biology

SN - 1545-7885

ER -