Functionalized carbon nanotubes for plasmid DNA gene delivery

Research output: Contribution to journalArticle

  • External authors:
  • D. Pantarotto
  • R Singh
  • D McCarthy
  • M. Erhardt
  • J.P. Briand
  • M Prato
  • A Bianco

Abstract

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

Bibliographical metadata

Original languageEnglish
Pages (from-to)5242-6
JournalAngewandte Chemie - International Edition
Volume43
Issue number39
Publication statusPublished - 2004