FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.Citation formats
Standard
FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder. / Hughes, Caryn; Iqbal-Wahid, Junaid; Brown, Michael; Shanks, Jonathan H; Eustace, Amanda; Denley, Helen; Hoskin, Peter J; West, Catharine; Clarke, Noel W; Gardner, Peter.
In: Journal of biophotonics, Vol. 6, No. 1, 01.2013, p. 73-87.Research output: Contribution to journal › Article › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - FTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.
AU - Hughes, Caryn
AU - Iqbal-Wahid, Junaid
AU - Brown, Michael
AU - Shanks, Jonathan H
AU - Eustace, Amanda
AU - Denley, Helen
AU - Hoskin, Peter J
AU - West, Catharine
AU - Clarke, Noel W
AU - Gardner, Peter
PY - 2013/1
Y1 - 2013/1
N2 - Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations.
AB - Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations.
KW - Clear cell
KW - Cluster analysis
KW - FTIR
KW - Infrared microspectroscopy
KW - Lipoid
KW - Principal component analysis
KW - Support vector machines
KW - Transitional cell carcinoma
KW - Urothelial carcinoma
U2 - 10.1002/jbio.201200126
DO - 10.1002/jbio.201200126
M3 - Article
C2 - 23125109
VL - 6
SP - 73
EP - 87
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 1
ER -